Body mass index, systemic inflammation and cognitive performance in adolescents: A cross-sectional study.

Autor: Caldú X; Departament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Neurociències, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Recerca Sant Joan de Déu, C/ Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain., Prats-Soteras X; Departament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Neurociències, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Recerca Sant Joan de Déu, C/ Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain., García-García I; Departament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Neurociències, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Clinique la Prairie, Montreux, Rue du Lac 142, 1815 Clarens, Switzerland., Prunell-Castañé A; Departament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Neurociències, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Recerca Sant Joan de Déu, C/ Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain., Sánchez-Garre C; Unitat d'Endocrinologia Pediàtrica, Departament de Pediatria, Hospital de Terrassa, Consorci Sanitari de Terrassa, Ctra Torrebonica s/n, 08227 Terrassa, Spain., Cano N; Unitat de Neuropsicologia, Hospital de Terrassa, Consorci Sanitari de Terrassa, Ctra Torrebonica s/n, 08227 Terrassa, Spain; Brain, Cognition and Behavior Clinical Research Group, Consorci Sanitari de Terrassa, Ctra Torrebonica s/n, 08227 Terrassa, Spain., Tor E; Centre d'Atenció Primària Terrassa Nord, Consorci Sanitari de Terrassa, Av del Vallès 451, 08226 Terrassa, Spain., Sender-Palacios MJ; Centre d'Atenció Primària Terrassa Nord, Consorci Sanitari de Terrassa, Av del Vallès 451, 08226 Terrassa, Spain., Ottino-González J; Division of Endocrinology, The Saban Research Institute, Children's Hospital Los Angeles, United States., Garolera M; Unitat de Neuropsicologia, Hospital de Terrassa, Consorci Sanitari de Terrassa, Ctra Torrebonica s/n, 08227 Terrassa, Spain; Brain, Cognition and Behavior Clinical Research Group, Consorci Sanitari de Terrassa, Ctra Torrebonica s/n, 08227 Terrassa, Spain. Electronic address: mgarolera@cst.cat., Jurado MÁ; Departament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Neurociències, Universitat de Barcelona, Pg. Vall d'Hebron, 171, 08035 Barcelona, Spain; Institut de Recerca Sant Joan de Déu, C/ Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain.
Jazyk: angličtina
Zdroj: Psychoneuroendocrinology [Psychoneuroendocrinology] 2023 Oct; Vol. 156, pp. 106298. Date of Electronic Publication: 2023 May 23.
DOI: 10.1016/j.psyneuen.2023.106298
Abstrakt: Background: Excessive body weight has been related to lower cognitive performance. One of the mechanisms through which excess body weight may affect cognition is inflammation.
Hypothesis: Our hypothesis is that both body mass index (BMI) and circulating levels of inflammatory biomarkers will be negatively related to cognitive performance.
Design: Cross-sectional study.
Setting: Users of the public health centres of the Consorci Sanitari de Terrassa (Terrassa, Spain) between 2010 and 2017 aged 12-21 years.
Participants: One hundred and five adolescents (46 normoweight, 18 overweight, 41 obese).
Measurements: Levels of high sensitivity C-reactive protein, interleukin 6, tumour necrosis factor α (TNFα) and fibrinogen were determined from blood samples. Cognitive performance was evaluated and six cognitive composites were obtained: working memory, cognitive flexibility, inhibitory control, decision-making, verbal memory, and fine motor speed. A single multivariate general lineal model was used to assess the influence of the four inflammatory biomarkers, as well as participants' BMI, sex, and age on the 6 cognitive indexes.
Results: An inverse relationship between BMI and inhibitory control (F = 5.688, p = .019; β = -0.212, p = .031), verbal memory (F = 5.404, p = .022; β = -0.255, p = .009) and fine motor speed (F = 9.038, p = .003; β = -0.319, p = .001) was observed. Levels of TNFα and fibrinogen were inversely related to inhibitory control (F = 5.055, p = .027; β = -0.226, p = .021) and verbal memory (F = 4.732, p = .032; β = -0.274, p = .005), respectively.
Limitations: The cross-sectional nature of the study, the use of cognitive tests designed for clinical purposes, and the use of BMI as a proxy for adiposity are limitations of our study that must be taken into account when interpreting results.
Conclusions: Our data indicate that some components of executive functions, together with verbal memory, are sensitive to specific obesity-related inflammatory agents at early ages.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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