Elevated sleep need in a stress-resilient Drosophila species.

Autor:	Yano J; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.; Molecular, Cellular & Integrative Physiology Interdepartmental PhD Program, UCLA, Los Angeles, CA 90095, USA., Nave C; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA., Larratt K; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA., Honey P; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.; Department of Neuroscience, Wellesley College, Wellesley, MA 02481, USA., Jingco C; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA., Roberts M; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA., Trotter D; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.; Molecular, Cellular & Integrative Physiology Interdepartmental PhD Program, UCLA, Los Angeles, CA 90095, USA., He X; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA., Elezi G; Pasarow Mass Spectrometry Laboratory, Jane & Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.; Cotsen Institute of Archaeology, UCLA, Los Angeles, CA 90095, USA., Whitelegge JP; Pasarow Mass Spectrometry Laboratory, Jane & Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA., Wasserman S; Department of Neuroscience, Wellesley College, Wellesley, MA 02481, USA., Donlea JM; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 May 28. Date of Electronic Publication: 2023 May 28.
DOI:	10.1101/2023.05.27.542279
Abstrakt:	Sleep is broadly conserved across the animal kingdom, but can vary widely between species. It is currently unclear which types of selective pressures and sleep regulatory mechanisms influence differences in sleep between species. The fruit fly Drosophila melanogaster has become a successful model system for examining sleep regulation and function, but little is known about the sleep patterns and need for sleep in many related fly species. Here, we find that Drosophila mojavensis , a fly species that has adapted to extreme desert environments, exhibits strong increases in sleep compared to D. melanogaster . Long-sleeping D. mojavensis show intact sleep homeostasis, indicating that these flies carry an elevated need for sleep. In addition, D. mojavensis exhibit altered abundance or distribution of several sleep/wake related neuromodulators and neuropeptides that are consistent with their reduced locomotor activity, and increased sleep. Finally, we find that in a nutrient-deprived environment, the sleep responses of individual D. mojavensis are correlated with their survival time. Our results demonstrate that D. mojavensis is a novel model for studying organisms with high sleep need, and for exploring sleep strategies that provide resilience in extreme environments. Competing Interests: Competing Interests The authors declare no competing interests.
Databáze:	MEDLINE
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