Tau Positron Emission Tomography and Neurocognitive Function Among Former Professional American-Style Football Players.

Autor: Dhaynaut M; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Grashow R; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA., Normandin MD; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Wu O; Athinoula A. Martinos Centre for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA., Marengi D Jr; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA., Terry DP; Vanderbilt Sports Concussion Center, Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Sanchez JS; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Weisskopf MG; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA., Speizer FE; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachsetts, USA., Taylor HA Jr; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.; Morehouse School of Medicine, Atlanta, Georgia, USA., Guehl NJ; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Seshadri S; The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UTHSA, San Antonio, Texas, USA., Beiser A; NHLBI's Framingham Heart Study, Framingham, Massachusetts, USA.; Department of Biostatistics and Neurology, Boston University School of Public Health, Boston, Massachusetts, USA., Daneshvar DH; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts 02129, USA., Johnson K; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Iverson GL; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts 02129, USA.; Department of Physical Medicine and Rehabilitation, Harvard Medical School, Charlestown, Massachusetts, USA.; Department of Physical Medicine and Rehabilitation, Schoen Adams Research Institute at Spaulding Rehabilitation, Charlestown, Massachusetts, USA.; Sports Concussion Program, MassGeneral Hospital for Children, Boston, Massachusetts, USA., Zafonte R; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts 02129, USA.; Department of Physical Medicine and Rehabilitation, Harvard Medical School, Charlestown, Massachusetts, USA., El Fakhri G; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Baggish AL; Football Players Health Study at Harvard University, Harvard Medical School, Boston, Massachusetts, USA.; Cardiovascular Performance Program, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Cardiology, Lausanne University Hospital (CHUV) and Institute for Sport Science, University of Lausanne (ISSUL), Lausanne, Switzerland.
Jazyk: angličtina
Zdroj: Journal of neurotrauma [J Neurotrauma] 2023 Aug; Vol. 40 (15-16), pp. 1614-1624. Date of Electronic Publication: 2023 Jun 28.
DOI: 10.1089/neu.2022.0454
Abstrakt: American-style football (ASF) players experience repetitive head impacts that may result in chronic traumatic encephalopathy neuropathological change (CTE-NC). At present, a definitive diagnosis of CTE-NC requires the identification of localized hyperphosphorylated Tau (p-Tau) after death via immunohistochemistry. Some studies suggest that positron emission tomography (PET) with the radiotracer [ 18 F]-Flortaucipir (FTP) may be capable of detecting p-Tau and thus establishing a diagnosis of CTE-NC among living former ASF players. To assess associations between FTP, football exposure, and objective neuropsychological measures among former professional ASF players, we conducted a study that compared former professional ASF players with age-matched male control participants without repetitive head impact exposure. Former ASF players and male controls underwent structural magnetic resonance imaging and PET using FTP for p-Tau and [ 11 C]-PiB for amyloid-β. Former players underwent neuropsychological testing. The ASF exposure was quantified as age at first exposure, professional career duration, concussion signs and symptoms burden, and total years of any football play. Neuropsychological testing included measures of memory, executive functioning, and depression symptom severity. P-Tau was quantified as FTP standardized uptake value ratios (SUVR) and [ 11 C]-PiB by distribution volume ratios (DVR) using cerebellar grey matter as the reference region. There were no significant differences in [ 18 F]-FTP uptake among former ASF players ( n  = 27, age = 50 ± 7 years) compared with control participants ( n  = 11, age = 55 ± 4 years), nor did any participant have significant amyloid-β burden. Among ASF participants, there were no associations between objective measures of neurocognitive functioning and [ 18 F]-FTP uptake. There was a marginally significant difference, however, between [ 18 F]-FTP uptake isolated to the entorhinal cortex among players in age-, position-, and race-adjusted models ( p  = 0.05) that may represent an area of future investigation. The absence of increased [ 18 F]-FTP uptake in brain regions previously implicated in CTE among former professional ASF players compared with controls questions the utility of [ 18 F]-FTP PET for clinical evaluation in this population.
Databáze: MEDLINE