Genomic characteristics of Mycobacterium tuberculosis isolates of cutaneous tuberculosis.

Autor:	Mei YM; Hospital of Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China., Zhang WY; Hospital of Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China., Sun JY; Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China.; Suzhou Institute of Systems Medicine, Suzhou, China., Jiang HQ; Hospital of Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China., Shi Y; Hospital of Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China., Xiong JS; Hospital of Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China., Wang L; Hospital of Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China., Chen YQ; Hospital of Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China., Long SY; Hospital of Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China., Pan C; Hospital of Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China., Luo T; Department of Pathogen Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, China., Wang HS; Hospital of Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China.
Jazyk:	angličtina
Zdroj:	Frontiers in microbiology [Front Microbiol] 2023 May 17; Vol. 14, pp. 1165916. Date of Electronic Publication: 2023 May 17 (Print Publication: 2023).
DOI:	10.3389/fmicb.2023.1165916
Abstrakt:	Objectives: Cutaneous tuberculosis with various manifestations can be divided into several clinical types according to the host's immune status and infective route. However, the etiological factors of this disease remain unclear. The objective of this study is to investigate the pathogens associated with the occurrence and different types of cutaneous tuberculosis. Methods: 58 Mycobacterium tuberculosis strains isolated from cutaneous tuberculosis over the last 20 years were sequenced and analyzed for genomic characteristics including lineage distribution, drug-resistance mutations, and mutations potentially associated with different sites of infection. Results: The M. tuberculosis strains from four major types of cutaneous tuberculosis and pulmonary tuberculosis shared similar genotypes and genomic composition. The strains isolated from cutaneous tuberculosis had a lower rate of drug resistance. Phylogenic analysis showed cutaneous tuberculosis and pulmonary tuberculosis isolates scattered on the three. Several SNPs in metabolism related genes exhibited a strong correlation with different infection sites. Conclusions: The different infection sites of TB may barely be affected by large genomic changes in M. tuberculosis isolates, but the significant difference in SNPs of drug resistance gene and metabolism-related genes still deserves more attention. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Mei, Zhang, Sun, Jiang, Shi, Xiong, Wang, Chen, Long, Pan, Luo and Wang.)
Databáze:	MEDLINE
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