The clock gene Per1 may exert diurnal control over hippocampal memory consolidation.

Autor: Bellfy L; Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA.; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA., Smies CW; Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA., Bernhardt AR; Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA., Bodinayake KK; Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA., Sebastian A; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA., Stuart EM; Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA., Wright DS; Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA., Lo CY; Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA., Murakami S; Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA., Boyd HM; Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA.; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA., von Abo MJ; Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA., Albert I; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA., Kwapis JL; Department of Biology, Pennsylvania State University, University Park, PA, 16802, USA. jlk855@psu.edu.; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA. jlk855@psu.edu.
Jazyk: angličtina
Zdroj: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2023 Nov; Vol. 48 (12), pp. 1789-1797. Date of Electronic Publication: 2023 Jun 01.
DOI: 10.1038/s41386-023-01616-1
Abstrakt: The circadian system influences many different biological processes, including memory performance. While the suprachiasmatic nucleus (SCN) functions as the brain's central pacemaker, downstream "satellite clocks" may also regulate local functions based on the time of day. Within the dorsal hippocampus (DH), for example, local molecular oscillations may contribute to time-of-day effects on memory. Here, we used the hippocampus-dependent Object Location Memory task to determine how memory is regulated across the day/night cycle in mice. First, we systematically determined which phase of memory (acquisition, consolidation, or retrieval) is modulated across the 24 h day. We found that mice show better long-term memory performance during the day than at night, an effect that was specifically attributed to diurnal changes in memory consolidation, as neither memory acquisition nor memory retrieval fluctuated across the day/night cycle. Using RNA-sequencing we identified the circadian clock gene Period1 (Per1) as a key mechanism capable of supporting this diurnal fluctuation in memory consolidation, as learning-induced Per1 oscillates in tandem with memory performance in the hippocampus. We then show that local knockdown of Per1 within the DH impairs spatial memory without affecting either the circadian rhythm or sleep behavior. Thus, Per1 may independently function within the DH to regulate memory in addition to its known role in regulating the circadian system within the SCN. Per1 may therefore exert local diurnal control over memory consolidation within the DH.
(© 2023. The Author(s), under exclusive licence to American College of Neuropsychopharmacology.)
Databáze: MEDLINE
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