A systems and computational biology perspective on advancing CAR therapy.

Autor: Tserunyan V; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA., Finley SD; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA; Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA, USA. Electronic address: sfinley@usc.edu.
Jazyk: angličtina
Zdroj: Seminars in cancer biology [Semin Cancer Biol] 2023 Sep; Vol. 94, pp. 34-49. Date of Electronic Publication: 2023 May 30.
DOI: 10.1016/j.semcancer.2023.05.009
Abstrakt: In the recent decades, chimeric antigen receptor (CAR) therapy signaled a new revolutionary approach to cancer treatment. This method seeks to engineer immune cells expressing an artificially designed receptor, which would endue those cells with the ability to recognize and eliminate tumor cells. While some CAR therapies received FDA approval and others are subject to clinical trials, many aspects of their workings remain elusive. Techniques of systems and computational biology have been frequently employed to explain the operating principles of CAR therapy and suggest further design improvements. In this review, we sought to provide a comprehensive account of those efforts. Specifically, we discuss various computational models of CAR therapy ranging in scale from organismal to molecular. Then, we describe the molecular and functional properties of costimulatory domains frequently incorporated in CAR structure. Finally, we describe the signaling cascades by which those costimulatory domains elicit cellular response against the target. We hope that this comprehensive summary of computational and experimental studies will further motivate the use of systems approaches in advancing CAR therapy.
Competing Interests: Declaration of Competing Interest Both authors would like to declare that they hold no conflict of interest. Furthermore, both authors do not expect to hold any such conflict in the future.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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