Underlying biochemical effects of intermittent fasting, exercise and honey on streptozotocin-induced liver damage in rats.

Autor: Agbonifo-Chijiokwu E; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State Nigeria., Nwangwa KE; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State Nigeria., Oyovwi MO; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State Nigeria.; Department of Hunan Physiology, Achievers University, Owo, Ondo State Nigeria., Ben-Azu B; Department of Pharmacology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State Nigeria., Naiho AO; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State Nigeria., Emojevwe V; Department of Physiology, University of Medical Sciences, Ondo, Ondo State Nigeria., Ohwin EP; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State Nigeria., Ehiwarior AP; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State Nigeria., Ojugbeli ET; Department of Medical Biochemistry, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State Nigeria., Nwabuoku SU; Department of Physiology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State Nigeria., Moke EG; Department of Pharmacology, Faculty of Basic Medical Science, College of Health Sciences, Delta State University, Abraka, Delta State Nigeria., Oghenetega BO; Department of Physiology, Faculty of Basic Medical Science, Babcock University, Illisan-Romo, Ogun State Nigeria.
Jazyk: angličtina
Zdroj: Journal of diabetes and metabolic disorders [J Diabetes Metab Disord] 2023 Jan 04; Vol. 22 (1), pp. 515-527. Date of Electronic Publication: 2023 Jan 04 (Print Publication: 2023).
DOI: 10.1007/s40200-022-01173-2
Abstrakt: Purpose: Derangements of liver transcriptional factors and enzymes have important implications in diabetes-induced related complications. Hence, this study which consists of two experimental phases was aimed at evaluating the possible underlying molecular mechanisms of intermittent fasting (IF), exercise starvation and honey in streptozotocin (STZ)-mediated liver damage in diabetic rats.
Methods: The diabetic rats were treated orally with distilled water (0.5 ml/kg), IF, starvation and honey at 1 g/kg body weight in the non-diabetic phase for four (4) weeks. After STZ injections, four (4) weeks of IF, exercise, starvation, and honey therapy were used as interventions prior to a biochemical evaluation of the liver.
Results: IF and exercise greatly decreased liver transcription factor (resistin, SREBP-1c), inflammatory cytokines/enzyme (TNF-α, IL-6, IL-1ß, MPO) as well as oxidative and nitrergic stress with correspondence increased liver PPAR-γ, IL-10, SOD, CAT and GSH in diabetic rats unlike starvation and honey regimen relative to diabetic controls. Furthermore, IF and exercise significantly improved hepatic glycogen synthase and decreased glycogen phosphorylase in diabetic rats compared to the diabetic control group, but starvation and honey therapy had no such influence. IF and exercise strategically reduces STZ-induced liver metabolic disorder via through modulation of liver transcriptional factors and inhibition of pro-inflammatory cytokines, oxido-nitrergic and adipokine signaling pathway.
Competing Interests: Conflicts of interestThere were no conflicts of interest decleared by the authors.
(© The Author(s), under exclusive licence to Tehran University of Medical Sciences 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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