Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study.

Autor: Kirschnick LB; Universidade Estadual de Campinas - UNICAMP, Piracicaba Dental School, Department of Oral Diagnosis, Piracicaba, SP, Brazil., Silveira FM; Universidad de la República - UDELAR, School of Dentistry, Division of Molecular Pathology, Montevideo, Uruguay., Schuch LF; Universidade Estadual de Campinas - UNICAMP, Piracicaba Dental School, Department of Oral Diagnosis, Piracicaba, SP, Brazil., Vasconcelos ACU; Universidade Federal de Pelotas - UFPel, School of Dentistry, Diagnostic Center for Oral Diseases, Pelotas, RS, Brazil., Gomes AP; Universidade Federal de Pelotas - UFPel, School of Dentistry, Diagnostic Center for Oral Diseases, Pelotas, RS, Brazil., Santos JND; Universidade Federal da Bahia - UFBA, School of Dentistry, Department of Pathology, Graduate Program in Dentistry and Health, Salvador, BA, Brazil., Santana DA; Universidade Federal da Bahia - UFBA, School of Dentistry, Department of Pathology, Graduate Program in Dentistry and Health, Salvador, BA, Brazil., Fonseca FP; Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery and Pathology, Belo Horizonte, MG, Brazil., Mesquita RA; Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery and Pathology, Belo Horizonte, MG, Brazil., Mendonça EF; Universidade Federal de Goias - UFG, School of Dentistry, Department of Stomatology, Goiânia, GO, Brazil., Sousa-Neto SS; Universidade Federal de Goias - UFG, School of Dentistry, Department of Stomatology, Goiânia, GO, Brazil., Pontes HAR; Universidade Federal do Pará - UFPA, João de Barros Barreto University Hospital, Department of Oral Pathology, Belém, PA, Brazil., Robinson L; University of Pretoria - UP, School of Dentistry, Department of Oral Pathology and Oral Biology, Pretoria, South Africa., Heerden WV; University of Pretoria - UP, School of Dentistry, Department of Oral Pathology and Oral Biology, Pretoria, South Africa., Carlos-Bregni R; Clinical Center of Head and Neck/Hospital Herrera Llerandi, Division of Pathology, Guatemala City, Guatemala., Tager EMJR; Clinical Center of Head and Neck/Hospital Herrera Llerandi, Division of Pathology, Guatemala City, Guatemala., Silva LCD; Universidade Estadual de Campinas - UNICAMP, Piracicaba Dental School, Department of Oral Diagnosis, Piracicaba, SP, Brazil., Zanella VG; Santa Casa de Misericórdia de Porto Alegre, Santa Rita Hospital, Department of Head and Neck Surgery, Porto Alegre, RS, Brazil., Rivero LF; Universidade Federal do Rio Grande do Sul - UFRGS, Faculty of Medicine, Department of Pathology, Porto Alegre, RS, Brazil., Bittencourt R; Universidade Federal do Rio Grande do Sul - UFRGS, Faculty of Medicine, Department of Pathology, Porto Alegre, RS, Brazil., Martins MAT; Universidade Federal do Rio Grande do Sul - UFRGS, Hospital de Clínicas de Porto Alegre, Department of Oral Medicine, Porto Alegre, RS, Brazil., Lopes MA; Universidade Estadual de Campinas - UNICAMP, Piracicaba Dental School, Department of Oral Diagnosis, Piracicaba, SP, Brazil., Wagner VP; University of Sheffield, Academic Unit of Oral and Maxillofacial Medicine and Pathology, Department of Clinical Dentistry, Sheffield, UK., Vargas PA; Universidade Estadual de Campinas - UNICAMP, Piracicaba Dental School, Department of Oral Diagnosis, Piracicaba, SP, Brazil., Martins MD; Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry, Department of Oral Pathology, Porto Alegre, RS, Brazil.
Jazyk: angličtina
Zdroj: Brazilian oral research [Braz Oral Res] 2023 May 29; Vol. 37, pp. e050. Date of Electronic Publication: 2023 May 29 (Print Publication: 2023).
DOI: 10.1590/1807-3107bor-2023.vol37.0050
Abstrakt: The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information. A total of 75 cases were included. Females (65.33%) with a mean age of 45.51 years were mostly affected. The lesions usually presented as an asymptomatic (64.28%) nodule (95.66%) in the parotid gland (70.68%). The association of two histopathological patterns was the most common finding (48.93%) and the tumors presented mainly conventional histopathological grades (86.11%). Surgical treatment was performed in the majority of the cases (59.19%). Local recurrence was observed in 20% of the informed cases, regional metastasis in 30.43%, and distant metastasis in 12.50%. The statistical analysis showed that the cases with a solid histopathological pattern (p=0.01), high-grade transformation (p=0.008), recurrence (p=0.007), and regional metastasis (p=0.03) were associated with poor survival. In conclusion, high histopathological transformation, presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region.
Databáze: MEDLINE