Localization, tissue biology and T cell state - implications for cancer immunotherapy.

Autor: Schenkel JM; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jmschenkel@mdanderson.org.; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jmschenkel@mdanderson.org.; Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jmschenkel@mdanderson.org., Pauken KE; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. kepauken@mdanderson.org.
Jazyk: angličtina
Zdroj: Nature reviews. Immunology [Nat Rev Immunol] 2023 Dec; Vol. 23 (12), pp. 807-823. Date of Electronic Publication: 2023 May 30.
DOI: 10.1038/s41577-023-00884-8
Abstrakt: Tissue localization is a critical determinant of T cell immunity. CD8 + T cells are contact-dependent killers, which requires them to physically be within the tissue of interest to kill peptide-MHC class I-bearing target cells. Following their migration and extravasation into tissues, T cells receive many extrinsic cues from the local microenvironment, and these signals shape T cell differentiation, fate and function. Because major organ systems are variable in their functions and compositions, they apply disparate pressures on T cells to adapt to the local microenvironment. Additional complexity arises in the context of malignant lesions (either primary or metastatic), and this has made understanding the factors that dictate T cell function and longevity in tumours challenging. Moreover, T cell differentiation state influences how cues from the microenvironment are interpreted by tissue-infiltrating T cells, highlighting the importance of T cell state in the context of tissue biology. Here, we review the intertwined nature of T cell differentiation state, location, survival and function, and explain how dysfunctional T cell populations can adopt features of tissue-resident memory T cells to persist in tumours. Finally, we discuss how these factors have shaped responses to cancer immunotherapy.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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