Bioinsecticidal activity of cajeput oil to pyrethroid-susceptible and -resistant mosquitoes.

Autor: Johnson EJ; Department of Entomology, University of Nebraska, 103 Entomology Hall, 1700 East Campus Mall, Lincoln, NE 68583, USA., McComic SE; Emerging Pathogens Institute, Department of Entomology and Nematology, University of Florida, 2055 Mowry Road, PO Box 100009, Gainesville, FL 32610, USA., Rault LC; Department of Entomology, University of Nebraska, 103 Entomology Hall, 1700 East Campus Mall, Lincoln, NE 68583, USA., Swale DR; Emerging Pathogens Institute, Department of Entomology and Nematology, University of Florida, 2055 Mowry Road, PO Box 100009, Gainesville, FL 32610, USA., Anderson TD; Department of Entomology, University of Nebraska, 103 Entomology Hall, 1700 East Campus Mall, Lincoln, NE 68583, USA. Electronic address: tanderson44@unl.edu.
Jazyk: angličtina
Zdroj: Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2023 Jun; Vol. 193, pp. 105458. Date of Electronic Publication: 2023 May 11.
DOI: 10.1016/j.pestbp.2023.105458
Abstrakt: Mosquito-borne diseases are a significant threat to human health. The frequent and repetitive application of insecticides can result in the selection of resistant mosquito populations leading to product failures for reducing community disease transmission. It is important that new interventions are discovered and developed for reducing mosquito populations and, in turn, protecting human health. Plant essential oils are promising chemical interventions for reducing mosquito populations. The myrtle family, Myrtaceae, has numerous species to be studied as potential bioinsecticides. Here, we combined toxicological, biochemical, and neurophysiological approaches to provide evidence for cajeput oil and terpene constituents to elicit bioinsecticidal activity to pyrethroid-susceptible and -resistant Aedes aegypti. We show cajeput oil terpenes to enhance cAMP production, increase ACh levels, inhibit in vivo and in vitro AChE activity, and disrupt spike discharge frequencies of the mosquito CNS. This study presents the first report on the bioinsecticidal activity of cajeput oil terpenes to pyrethroid-susceptible and -resistant mosquitoes and provides comparative data for the octopaminergic system as a putative molecular target for the bioinsecticides with implications for resistance management.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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