A Self-Regenerating Artificial Cell, that is One Step Closer to Living Cells: Challenges and Perspectives.

Autor: Tror S; Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, 04107, Republic of Korea., Jeon S; Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, 04107, Republic of Korea., Nguyen HT; Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, 04107, Republic of Korea., Huh E; Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, 04107, Republic of Korea., Shin K; Department of Chemistry and Institute of Biological Interfaces, Sogang University, Seoul, 04107, Republic of Korea.
Jazyk: angličtina
Zdroj: Small methods [Small Methods] 2023 Dec; Vol. 7 (12), pp. e2300182. Date of Electronic Publication: 2023 May 28.
DOI: 10.1002/smtd.202300182
Abstrakt: Controllable, self-regenerating artificial cells (SRACs) can be a vital advancement in the field of synthetic biology, which seeks to create living cells by recombining various biological molecules in the lab. This represents, more importantly, the first step on a long journey toward creating reproductive cells from rather fragmentary biochemical mimics. However, it is still a difficult task to replicate the complex processes involved in cell regeneration, such as genetic material replication and cell membrane division, in artificially created spaces. This review highlights recent advances in the field of controllable, SRACs and the strategies to achieve the goal of creating such cells. Self-regenerating cells start by replicating DNA and transferring it to a location where proteins can be synthesized. Functional but essential proteins must be synthesized for sustained energy generation and survival needs and function in the same liposomal space. Finally, self-division and repeated cycling lead to autonomous, self-regenerating cells. The pursuit of controllable, SRACs will enable authors to make bold advances in understanding life at the cellular level, ultimately providing an opportunity to use this knowledge to understand the nature of life.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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