Diet and Exercise Exert a Differential Effect on Glucose Metabolism Markers According to the Degree of NAFLD Severity.

Autor:	Bianco A; Laboratory of Epidemiology and Statistics, National Institute of Gastroenterology-IRCCS 'S. de Bellis', Via Turi, 70013 Castellana Grotte, BA, Italy., Franco I; Laboratory of Epidemiology and Statistics, National Institute of Gastroenterology-IRCCS 'S. de Bellis', Via Turi, 70013 Castellana Grotte, BA, Italy., Curci R; Laboratory of Epidemiology and Statistics, National Institute of Gastroenterology-IRCCS 'S. de Bellis', Via Turi, 70013 Castellana Grotte, BA, Italy., Bonfiglio C; Laboratory of Epidemiology and Statistics, National Institute of Gastroenterology-IRCCS 'S. de Bellis', Via Turi, 70013 Castellana Grotte, BA, Italy., Campanella A; Laboratory of Epidemiology and Statistics, National Institute of Gastroenterology-IRCCS 'S. de Bellis', Via Turi, 70013 Castellana Grotte, BA, Italy., Mirizzi A; Laboratory of Epidemiology and Statistics, National Institute of Gastroenterology-IRCCS 'S. de Bellis', Via Turi, 70013 Castellana Grotte, BA, Italy., Fucilli F; Department of Radiology, National Institute of Gastroenterology-IRCCS 'S. de Bellis', 70013 Castellana Grotte, BA, Italy., Di Giovanni G; Department of Radiology, National Institute of Gastroenterology-IRCCS 'S. de Bellis', 70013 Castellana Grotte, BA, Italy., Giampaolo N; Department of Radiology, National Institute of Gastroenterology-IRCCS 'S. de Bellis', 70013 Castellana Grotte, BA, Italy., Pesole PL; Laboratory of Clinical Pathology, National Institute of Gastroenterology-IRCCS 'S. de Bellis', 70013 Castellana Grotte, BA, Italy., Osella AR; Laboratory of Epidemiology and Statistics, National Institute of Gastroenterology-IRCCS 'S. de Bellis', Via Turi, 70013 Castellana Grotte, BA, Italy.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2023 May 10; Vol. 15 (10). Date of Electronic Publication: 2023 May 10.
DOI:	10.3390/nu15102252
Abstrakt:	Background: Non-Alcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes (T2D) are highly prevalent diseases worldwide. Insulin Resistance (IR) is the common denominator of the two conditions even if the precise timing of onset is unknown. Lifestyle change remains the most effective treatment to manage NAFLD. This study aimed to estimate the effect of the Low Glycemic Index Mediterranean Diet (LGIMD) and exercise (aerobic and resistance) over a one-year period on the longitudinal trajectories of glucose metabolism regulatory pathways. Materials and Methods: In this observational study, 58 subjects (aged 18-65) with different degrees of NAFLD severity were enrolled by the National Institute of Gastroenterology-IRCCS "S. de Bellis", to follow a 12-month program of combined exercise and diet. Results: The mean age was 55 ± 7 years old. Gender was equally distributed among NAFLD categories. There was a statistically significant main effect of time for glycosylated hemoglobin (Hb1Ac) over the whole period (-5.41, 95% CI: -7.51; -3.32). There was a steady, statistically significant decrease of HbA1c in participants with moderate and severe NAFLD whereas this effect was observed after the 9th month in those with mild NAFLD. Conclusions: The proposed program significantly improves glucose metabolism parameters, especially HbA1c.
Databáze:	MEDLINE
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