A Disease-Specific Antibiogram to Evaluate Empiric Coverage Patterns in Fournier's Gangrene.

Autor: Koch GE; Department of Urology, Vanderbilt University Medical Center, Nashville, TN. Electronic address: George.e.koch@vumc.org., Launer BM; Department of Urology, Vanderbilt University Medical Center, Nashville, TN., Li AN; Vanderbilt University School of Medicine, Nashville, TN., Johnsen NV; Department of Urology, Vanderbilt University Medical Center, Nashville, TN.
Jazyk: angličtina
Zdroj: Urology [Urology] 2023 Aug; Vol. 178, pp. 162-166. Date of Electronic Publication: 2023 May 24.
DOI: 10.1016/j.urology.2023.05.014
Abstrakt: Objective: To analyze our local antibiogram and antibiotic resistance patterns given concern for multidrug-resistant and fungal organisms in contemporary series detailing causative organisms in Fournier's Gangrene (FG).
Methods: All patients from 2018 to 2022 were identified from the institutional FG registry. Microorganisms and sensitivities were collected from operative tissue cultures. The primary outcome of this study was the adequacy of our empiric. Secondary outcomes included the rate of bacteremia, the concordance of blood cultures and tissue cultures, and the rate of fungal tissue infections.
Results: Escherichia coli and Streptococcus anginosus were most common, identified in 12 patients each (20.0%). Enterococcus faecalis (9, 15.0%), S agalactiae (8, 13.3%) and mixed cultures without a predominant organism (9, 15.0%) were also common. A fungal organism was identified in 9 (15.0%) patients. Patients who were started on Infectious Diseases Society of America guideline adherent antibiotic regimen were not significantly different in terms of bacteremia rate (P = .86), mortality (P = .25), length of stay (P = .27), or final antibiotic duration (P = .43) when compared to those on alternative regimens. Patients with a tissue culture positive for a fungal organism were not significantly different in terms of Fournier's Gangrene Severity Index (P = .25) or length of stay (P = .19).
Conclusion: Local disease-specific antibiograms can be a powerful tool to guide empiric antibiotic therapy in FG. Although fungal infections are responsible for a majority of the gaps in empiric antimicrobial coverage at our institution they were present in only 15% of patients and their effect on outcomes does not justify addition of empiric antifungal agents.
Competing Interests: Declaration of Competing Interest None Declared.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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