| Autor: |
Fontes J; Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal., Martin VZ; BoneLab-Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-393 Porto, Portugal.; LAQV/REQUIMTE-Laboratório Associado para a Química Verde/Rede de Química e Tecnologia, University of Porto, 4100-007 Porto, Portugal., Resende M; Faculty of Dental Medicine, University of Porto, 4200-393 Porto, Portugal., Colaço B; LAQV/REQUIMTE-Laboratório Associado para a Química Verde/Rede de Química e Tecnologia, University of Porto, 4100-007 Porto, Portugal.; Department of Zootechnics, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.; Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.; Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 5000-801 Vila Real, Portugal., Gomes PS; BoneLab-Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-393 Porto, Portugal.; LAQV/REQUIMTE-Laboratório Associado para a Química Verde/Rede de Química e Tecnologia, University of Porto, 4100-007 Porto, Portugal., Amarante JM; Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal. |
| Abstrakt: |
This study aimed to address the stability of orthodontic mini-implants submitted to an immediate orthodontic functional load, in splinted or unsplinted conditions, further characterizing the histomorphometric parameters of the neighboring bone tissue, in an in vivo experimental model. Mini-implants (1.4 × 6.0 mm) were placed in the proximal tibia of New Zealand White rabbits and immediately loaded with a 150 g force. Tissue healing was characterized within 8 weeks. Microtomography was used to assess the mini-implants' tipping and bone histomorphometric indexes. Loaded implants were evaluated in splinted and unsplinted conditions, with data being compared to that of unloaded mini-implants with the Kruskal-Wallis nonparametric test, followed by Dunn's multiple comparison tests. The splinting of mini-implants submitted to immediate orthodontic loading significantly reduced the tipping to levels similar to those of unloaded mini-implants. Immediate loading further increased the histomorphometric indexes associated with bone formation at the peri-implant region, in both splinted and unsplinted conditions, with no significant differences between the tension and compression regions. Accordingly, within this experimental setting, splinting was found to lessen tipping and mini-implants' displacement, without affecting the increased bone formation at the peri-implant region, induced by a functional orthodontic load. |
