Hyperplasia of Arachnoid Trabecular Cells: A Hitherto Undescribed Lesion Observed in the Setting of Neurofibromatosis Type 1.

Autor:	Maehara T; Department of Human Pathology, Gunma University Graduate School of Medicine., Yamazaki A; Department of Human Pathology, Gunma University Graduate School of Medicine., Kawabata-Iwakawa R; Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research, Gunma University., Fukuoka K; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama., Akazawa A; Department of Neurosurgery, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui., Okura N; Department of Radiology, International University of Health and Welfare, School of Medicine, Narita., Nishiyama M; Gunma University, Maebashi., Nassiri F; Division of Neurosurgery, Department of Surgery, University of Toronto.; MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto.; Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Wang JZ; Division of Neurosurgery, Department of Surgery, University of Toronto., Zadeh G; Division of Neurosurgery, Department of Surgery, University of Toronto.; MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto.; Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Kikuta K; Department of Neurosurgery, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui., Oka H; Department of Neurosurgery, Kitasato University Medical Center, Kitamoto., Hirato J; Department of Human Pathology, Gunma University Graduate School of Medicine.; Department of Pathology, Public Tomioka General Hospital, Tomioka, Japan., Yokoo H; Department of Human Pathology, Gunma University Graduate School of Medicine., Nobusawa S; Department of Human Pathology, Gunma University Graduate School of Medicine.
Jazyk:	angličtina
Zdroj:	The American journal of surgical pathology [Am J Surg Pathol] 2023 Jul 01; Vol. 47 (7), pp. 819-825. Date of Electronic Publication: 2023 May 25.
DOI:	10.1097/PAS.0000000000002056
Abstrakt:	Central nervous system manifestations, a variety of benign and malignant tumors as well as non-neoplastic abnormalities, are found in over 70% of neurofibromatosis type 1 (NF1) patients. Herein, we report hitherto undescribed space-occupying lesions in the setting of NF1. We aimed to clarify their characteristics, especially whether they represent neoplastic or non-neoplastic (hyperplastic) lesions. All 3 cases were preoperatively assessed as non-neoplastic; 2 and 1 cases were suspected to be arachnoid cysts and dilation of subarachnoid space, respectively. However, all lesions were revealed to be whitish jelly-like masses by operation, and the histology composed of spindle cells resembling arachnoid trabecular cells with moderate cellularity and cellular uniformity gave an impression that these lesions may be neoplastic. In contrast, electron microscopic analysis showed that the characteristics of these cells were compatible with those of normal arachnoid trabecular cells. Furthermore, whole-exome sequencing and array comparative genomic hybridization did not show any obvious alterations suggestive of their neoplastic nature. DNA methylation analysis demonstrated that these lesions were epigenetically distinct not only from meningiomas but also from normal healthy meninges. In conclusion, considering the clinicopathologic aspects of the present lesions and the results of the molecular analysis that failed to suggest their neoplastic nature, they may represent previously unrecognized rare hyperplasia of arachnoid trabecular cells, which may be associated with NF1. Competing Interests: Conflicts of Interest and Source of Funding: Partially supported by the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, through the University Reform Action Plan “Gunma University Initiative for Advanced Research (GIAR).” The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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