| Autor: |
Loucks EB; Department of Epidemiology Brown University School of Public Health Providence RI.; Department of Behavioral Sciences Brown University School of Public Health Providence RI.; Department of Medicine The Warren Alpert Medical School of Brown University Providence RI.; Mindfulness Center at Brown University Providence RI., Schuman-Olivier Z; Cambridge Health Alliance Cambridge MA.; Harvard Medical School Boston MA.; Center for Mindfulness and Compassion Cambridge MA., Saadeh FB; Department of Epidemiology Brown University School of Public Health Providence RI.; Mindfulness Center at Brown University Providence RI., Scarpaci MM; Hassenfeld Child Health Innovation Institute Brown University School of Public Health Providence RI., Nardi WR; Department of Behavioral Sciences Brown University School of Public Health Providence RI.; Mindfulness Center at Brown University Providence RI., Proulx JA; Department of Behavioral Sciences Brown University School of Public Health Providence RI.; Mindfulness Center at Brown University Providence RI., Gutman R; Department of Biostatistics Brown University School of Public Health Providence RI., King J; Worcester Polytechnic Institute Worcester MA., Britton WB; Mindfulness Center at Brown University Providence RI.; Department of Psychiatry and Human Behavior The Warren Alpert Medical School of Brown University Providence RI., Kronish IM; Center for Behavioral Cardiovascular Health Columbia University Irving Medical Center New York NY. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Heart Association [J Am Heart Assoc] 2023 Jun 06; Vol. 12 (11), pp. e028712. Date of Electronic Publication: 2023 May 23. |
| DOI: |
10.1161/JAHA.122.028712 |
| Abstrakt: |
Background Hypertension is a leading risk factor for cardiovascular disease. Despite availability of effective lifestyle and medication treatments, blood pressure (BP) is poorly controlled in the United States. Mindfulness training may offer a novel approach to improve BP control. The objective was to evaluate the effects of Mindfulness-Based Blood Pressure Reduction (MB-BP) versus enhanced usual care control on unattended office systolic BP. Methods and Results Methods included a parallel-group phase 2 randomized clinical trial conducted from June 2017 to November 2020. Follow-up time was 6 months. Outcome assessors and data analyst were blinded to group allocation. Participants had elevated unattended office BP (≥120/80 mm Hg). We randomized 201 participants to MB-BP (n=101) or enhanced usual care control (n=100). MB-BP is a mindfulness-based program adapted for elevated BP. Loss-to-follow-up was 17.4%. The primary outcome was change in unattended office systolic BP at 6 months. A total of 201 participants (58.7% women; 81.1% non-Hispanic White race and ethnicity; mean age, 59.5 years) were randomized. Results showed that MB-BP was associated with a 5.9-mm Hg reduction (95% CI, -9.1 to -2.8 mm Hg) in systolic BP from baseline and outperformed the control group by 4.5 mm Hg at 6 months (95% CI, -9.0 to -0.1 mm Hg) in prespecified analyses. Plausible mechanisms with evidence to be impacted by MB-BP versus control were sedentary activity (-350.8 sitting min/wk [95% CI, -636.5 to -65.1] sitting min/wk), Dietary Approaches to Stop Hypertension diet (0.32 score [95% CI, -0.04 to 0.67]), and mindfulness (7.3 score [95% CI, 3.0-11.6]). Conclusions A mindfulness-based program adapted for individuals with elevated BP showed clinically relevant reductions in systolic BP compared with enhanced usual care. Mindfulness training may be a useful approach to improve BP. Registration URL: https://www.clinicaltrials.gov; Unique identifiers: NCT03256890 and NCT03859076. |
| Databáze: |
MEDLINE |
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