Preventing the amyloid-beta peptides accumulation on the cell membrane by applying GHz electric fields: A molecular dynamic simulation.

Autor: Salehi N; Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran., Lohrasebi A; Department of Physics, University of Isfahan, Isfahan, 81746-73441, Iran. Electronic address: lohrasebi@phys.ui.ac.ir., Bordbar AK; Department of Chemistry and Biochemistry, California Polytechnic State University, San Luis Obispo, CA, USA. Electronic address: bordbar@calpoly.edu.
Jazyk: angličtina
Zdroj: Journal of molecular graphics & modelling [J Mol Graph Model] 2023 Sep; Vol. 123, pp. 108516. Date of Electronic Publication: 2023 May 18.
DOI: 10.1016/j.jmgm.2023.108516
Abstrakt: Alzheimer's disease is associated with accumulating different amyloid peptides on the nerve cell membranes. The non-thermal effects of the GHz electric fields in this topic have yet to be well recognized. Hence, in this study, the impacts of 1 and 5 GHz electric fields on the amyloid peptide proteins accumulation on the cell membrane have been investigated, utilizing molecular dynamics (MD) simulation. The obtained results indicated that this range of electric fields did not significantly affect the peptide structure. Moreover, it was found that the peptide penetration into the membrane was increased as the field frequency was increased when the system was exposed to a 20 mv/nm oscillating electric field. In addition, it was observed that the protein-membrane interaction is reduced significantly in the presence of the 70 mv/nm electric field. The molecular level results reported in this study could be helpful in better understanding Alzheimer's disease.
Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interest regarding the publication of this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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