Gene expression in the intestine of newborn piglets after hypoxia-reoxygenation.
Autor: | Dotinga BM; Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Bao M; Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.bao@umcg.nl., Solberg R; Division of Pediatric and Adolescent Medicine, Department of Pediatric Research, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway., Saugstad OD; Division of Pediatric and Adolescent Medicine, Department of Pediatric Research, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway., Hulscher JBF; Division of Pediatric Surgery, Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands., Bos AF; Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Plösch T; Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Perinatal Neurobiology, Department of Human Medicine, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany., Kooi EMW; Division of Neonatology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. |
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Jazyk: | angličtina |
Zdroj: | Pediatric research [Pediatr Res] 2023 Oct; Vol. 94 (4), pp. 1365-1372. Date of Electronic Publication: 2023 May 19. |
DOI: | 10.1038/s41390-023-02657-4 |
Abstrakt: | Background: In preterm infants, intestinal hypoxia may partly contribute to the pathophysiology of necrotizing enterocolitis through changes in gene expression. Splanchnic hypoxia can be detected with monitoring of regional splanchnic oxygen saturation (r Methods: Forty-two newborn piglets were randomized to control or intervention groups. Intervention groups were subjected to hypoxia until they were acidotic and hypotensive. Next, they were reoxygenated for 30 min according to randomization, i.e., 21% O Results: The expression of selected genes was not significantly different between control and intervention groups. No associations between mean r Conclusion: Our study suggests that hypoxia and reoxygenation cause reduced vascular adaptability, which seems to be associated with the upregulation of apoptosis and downregulation of inflammation. Impact: Our results provide important insight into the (patho)physiological significance of changes in the variability of r (© 2023. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.) |
Databáze: | MEDLINE |
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