Clinical predictors of Covid-19 mortality in a tertiary hospital in Lagos, Nigeria: A retrospective cohort study.

Autor:	Akase IE; Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria., Akintan PE; Department of Pediatrics, College of Medicine, University of Lagos, Lagos, Nigeria., Otrofanowei E; Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria., Olopade OB; Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria., Olorunfemi G; Division of Epidemiology and Biostatistics, School of Public Health, University of Witwatersrand, Johannesburg, South Africa., Opawoye A; Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria., Ima-Edomwomyi UE; Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria., Akinbolagbe YO; Department of Pediatrics, College of Medicine, University of Lagos, Lagos, Nigeria., Agabi OP; Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria., Nmadu DA; Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria., Akinbode GO; Department of Surgery, Lagos University Teaching Hospital, Lagos, Nigeria., Olasope AC; Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria., Ogundare A; Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria., Bolarinwa AB; Department of Hematology and Blood Transfusion, Lagos University Teaching Hospital, Lagos, Nigeria., Otokiti EO; Department of Hematology and Blood Transfusion, Lagos University Teaching Hospital, Lagos, Nigeria., Enajeroh PJ; Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria., Karami M; Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria., Esezobor CI; Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria., Oshodi Y; Department of Psychiatry, College of Medicine, University of Lagos, Lagos, Nigeria., Oluwole AA; Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria., Adeyemo WL; Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Lagos, Nigeria., Bode CO; Department of Surgery, College of Medicine, University of Lagos, Lagos, Nigeria.
Jazyk:	angličtina
Zdroj:	Nigerian journal of clinical practice [Niger J Clin Pract] 2023 Apr; Vol. 26 (4), pp. 424-431.
DOI:	10.4103/njcp.njcp_454_22
Abstrakt:	Background: The predictors of mortality among patients presenting with severe to critical disease in Nigeria are presently unknown. Aim: The aim of this study was to identify the predictors of mortality among patients with COVID-19 presenting for admission in a tertiary referral hospital in Lagos, Nigeria. Patients and Methods: The study was a retrospective study. Patients' sociodemographics, clinical characteristics, comorbidities, complications, treatment outcomes, and hospital duration were documented. Pearson's Chi-square, Fischer's Exact test, or Student's t-test were used to assess the relationship between the variables and mortality. To compare the survival experience across medical comorbidities, Kaplan Meir plots and life tables were used. Univariable and multivariable Cox-proportional hazard analyses were conducted. Results: A total of 734 patients were recruited. Participants' age ranged from five months to 92 years, with a mean ± SD of 47.4 ± 17.2 years, and a male preponderance (58.5% vs. 41.5%). The mortality rate was 9.07 per thousand person-days. About 73.9% (n = 51/69) of the deceased had one or more co-morbidities, compared to 41.6% (252/606) of those discharged. Patients who were older than 50 years, with diabetes mellitus, hypertension, chronic renal illness, and cancer had a statistically significant relationship with mortality. Conclusion: These findings call for a more comprehensive approach to the control of non-communicable diseases, the allocation of sufficient resources for ICU care during outbreaks, an improvement in the quality of health care available to Nigerians, and further research into the relationship between obesity and COVID-19 in Nigerians. Competing Interests: None
Databáze:	MEDLINE
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