Biological and structural phenotypes associated with neurodevelopmental outcomes in congenital heart disease.

Autor:	Verrall CE; Heart Centre for Children, The Children's Hospital at Westmead, Sydney, Australia.; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia., Patel S; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia., Travitz L; Division of Developmental Biology and the Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Tchieu J; Division of Developmental Biology and the Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Dale RC; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia., Kasparian NA; Center for Heart Disease and Mental Health, Heart Institute and the Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, OH, USA., Winlaw DS; Cardiothoracic Surgery, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Blue GM; Heart Centre for Children, The Children's Hospital at Westmead, Sydney, Australia.; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Jazyk:	angličtina
Zdroj:	Translational pediatrics [Transl Pediatr] 2023 Apr 29; Vol. 12 (4), pp. 768-786. Date of Electronic Publication: 2023 Apr 27.
DOI:	10.21037/tp-22-687
Abstrakt:	Neurodevelopmental disability (NDD) is recognised as one of the most common comorbidities in children with congenital heart disease (CHD) and is associated with altered brain structure and growth throughout the life course. Causes and contributors underpinning the CHD and NDD paradigm are not fully understood, and likely include innate patient factors, such as genetic and epigenetic factors, prenatal haemodynamic consequences as a result of the heart defect, and factors affecting the fetal-placental-maternal environment, such as placental pathology, maternal diet, psychological stress and autoimmune disease. Additional postnatal factors, including the type and complexity of disease and other clinical factors such as prematurity, peri-operative factors and socioeconomic factors are also expected to play a role in determining the final presentation of the NDD. Despite significant advances in knowledge and strategies to optimise outcomes, the extent to which adverse neurodevelopment can be modified remains unknown. Understanding biological and structural phenotypes associated with NDD in CHD are vital for understanding disease mechanisms, which in turn will advance the development of effective intervention strategies for those at risk. This review article summarises our current knowledge surrounding biological, structural, and genetic contributors to NDD in CHD and describes avenues for future research; highlighting the need for translational studies that bridge the gap between basic science and clinical practice. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-22-687/coif). The column “Pediatric Heart” was commissioned by the editorial office without any funding or sponsorship. JT was supported by the Office of the Assistant Secretary of Defense for Health Affairs through the Autism Research Program (Award No. W81XWH-21-ARP-CDA). NAK receives funding from the National Heart Foundation of Australia, Additional Ventures and the National Health and Medical Research Council of Australia (research grant only, payment made to the institution). The authors have no other conflicts of interest to declare. (2023 Translational Pediatrics. All rights reserved.)
Databáze:	MEDLINE
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