Improved Resting-State Functional MRI Using Multi-Echo Echo-Planar Imaging on a Compact 3T MRI Scanner with High-Performance Gradients.

Autor: Kang D; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., In MH; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Jo HJ; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.; Department of Physiology, Hanyang University, Seoul 04763, Republic of Korea., Halverson MA; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Meyer NK; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN 55905, USA., Ahmed Z; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Gray EM; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Madhavan R; GE Global Research, Niskayuna, NY 12309, USA., Foo TK; GE Global Research, Niskayuna, NY 12309, USA., Fernandez B; GE Healthcare, 78530 Buc, France., Black DF; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Welker KM; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Trzasko JD; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Huston J 3rd; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Bernstein MA; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Shu Y; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Jazyk: angličtina
Zdroj: Sensors (Basel, Switzerland) [Sensors (Basel)] 2023 Apr 27; Vol. 23 (9). Date of Electronic Publication: 2023 Apr 27.
DOI: 10.3390/s23094329
Abstrakt: In blood-oxygen-level-dependent (BOLD)-based resting-state functional (RS-fMRI) studies, usage of multi-echo echo-planar-imaging (ME-EPI) is limited due to unacceptable late echo times when high spatial resolution is used. Equipped with high-performance gradients, the compact 3T MRI system (C3T) enables a three-echo whole-brain ME-EPI protocol with smaller than 2.5 mm isotropic voxel and shorter than 1 s repetition time, as required in landmark fMRI studies. The performance of the ME-EPI was comprehensively evaluated with signal variance reduction and region-of-interest-, seed- and independent-component-analysis-based functional connectivity analyses and compared with a counterpart of single-echo EPI with the shortest TR possible. Through the multi-echo combination, the thermal noise level is reduced. Functional connectivity, as well as signal intensity, are recovered in the medial orbital sulcus and anterior transverse collateral sulcus in ME-EPI. It is demonstrated that ME-EPI provides superior sensitivity and accuracy for detecting functional connectivity and/or brain networks in comparison with single-echo EPI. In conclusion, the high-performance gradient enabled high-spatial-temporal resolution ME-EPI would be the method of choice for RS-fMRI study on the C3T.
Databáze: MEDLINE
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