[Subclinical markers of liver damage in patients with arterial hypertension and obesity].

Autor:	Sadulaeva IA; Yevdokimov Moscow State University of Medicine and Dentistry., Yushchuk EN; Yevdokimov Moscow State University of Medicine and Dentistry., Khalikova LF; Yevdokimov Moscow State University of Medicine and Dentistry., Krikunova OV; Yevdokimov Moscow State University of Medicine and Dentistry., Trofimenko OS; Yevdokimov Moscow State University of Medicine and Dentistry., Medvedeva EG; Yevdokimov Moscow State University of Medicine and Dentistry.
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2023 Jan 16; Vol. 94 (12), pp. 1367-1373. Date of Electronic Publication: 2023 Jan 16.
DOI:	10.26442/00403660.2022.12.201993
Abstrakt:	Aim: To investigate the possibility of preclinical detection of liver damage in patients with hypertension and obesity. Materials and Methods: The study included 168 patients with hypertension aged 30 to 60 years. All patients underwent general clinical and laboratory-instrumental examination, including ultrasound of the abdominal organs with Doppler assessment of blood flow and determination of markers such as ALT, AST, TG, lipid profile indicators at inclusion, after a month, three months and nine months. Results: Depending on the presence of obesity, all patients with hypertension were divided into two groups. Obese patients had a statistically significant increase in office blood pressure, FSI, the ratio of TG and LDL-C to HDL-C, a more significant higher average levels of glucose, TG and ALT levels, as well as impaired hepatic blood flow according to ultrasound. Conclusion: Indicators of FSI, ALT/AST ratio, ratio of TG and LDL-С to HDL-C as well as assessment of hepatic blood flow indicators can be used for early diagnosis of nonalcoholic fatty liver disease, as they predict liver steatosis.
Databáze:	MEDLINE
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