Shared Heritability of Blood Pressure and Pulse Wave Velocity: Insights From the STANISLAS Cohort.

Autor:	Xhaard C; Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France (C.X., E.B., F.Z., P.R., N.G.)., de Villemereuil P; Institut de Systématique, Évolution, Biodiversité (ISYEB), École Pratique des Hautes Études | PSL, MNHN, CNRS, SU, UA, Paris, France (P.d.V.)., Benetos A; CHRU-Nancy Pôle Maladies du vieillissement, Gérontologie et Soins Palliatifs and Fédération Hospitalo-Universitaire CARTAGE-PROFILES Université de Lorraine, Nancy, France (A.B.)., Bozec E; Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France (C.X., E.B., F.Z., P.R., N.G.)., Dandine-Roulland C; Centre National de Recherche en Génomique Humaine, Institut François Jacob, CEA, Université Paris-Saclay, Evry, France (C.D.-R., E.L.F.)., Le Floch E; Centre National de Recherche en Génomique Humaine, Institut François Jacob, CEA, Université Paris-Saclay, Evry, France (C.D.-R., E.L.F.)., Regnault V; Inserm DCAC Université de Lorraine, Nancy, France (V.R., P.L.)., Lacolley P; Inserm DCAC Université de Lorraine, Nancy, France (V.R., P.L.)., Zannad F; Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France (C.X., E.B., F.Z., P.R., N.G.)., Rossignol P; Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France (C.X., E.B., F.Z., P.R., N.G.)., Girerd N; Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM 1116, CHRU de Nancy, FCRIN INI-CRCT, Nancy, France (C.X., E.B., F.Z., P.R., N.G.).
Jazyk:	angličtina
Zdroj:	Hypertension (Dallas, Tex. : 1979) [Hypertension] 2023 Jul; Vol. 80 (7), pp. 1526-1533. Date of Electronic Publication: 2023 May 11.
DOI:	10.1161/HYPERTENSIONAHA.122.20740
Abstrakt:	Background: Pulse wave velocity (PWV) is a marker of arterial stiffness, which is intrinsically highly correlated with blood pressure (BP). However, the interplay of PWV and BP heritability has not been extensively studied. This study aimed to estimate the heritability of PWV and BP and determine the genetic correlation between PWV and BP. Methods: The heritability of PWV and BP was estimated in 1080 subjects from the STANISLAS (Suivi Temporaire Annuel Non-Invasif de la Santé des Lorrains Assurés Sociaux) cohort with at least one relative using a linear mixed model within one frequentist and one Bayesian framework implemented, respectively, in the Gaston and MCMCglmm R packages. Then their genetic correlations were also estimated. Results: The heritability estimations for PWV were within the same range of the heritability of systolic BP and diastolic BP (23%, 19%, and 27%, respectively). Daytime heritability of BP was higher than nighttime BP. In addition, phenotypic correlations between PWV and systolic BP/diastolic BP were, respectively, 0.34 and 0.23, whereas nonsignificant genetic correlations were 0.08 and 0.22 respectively, indicating that PWV and diastolic BP shared more polygenic codeterminants than PWV and systolic BP. Conclusions: Our results suggest that the heritability of PWV is >20% and within the same range as BP heritability. It also suggests that the link between PWV and BP goes beyond phenotypic association: PWV and BP (in particular diastolic BP) share common genetic determinants. This genetic interdependence of PWV and BP appears largely polygenic. Competing Interests: Disclosures None.
Databáze:	MEDLINE
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