Health related quality of life in the domain of physical activity predicts confirmed disability progression in people with relapsing remitting multiple sclerosis.

Autor: Abbadessa G; II Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy., Ponzano M; Department of Health Sciences - Section of Biostatistics University of Genoa, Italy., Bile F; II Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy., Miele G; II Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy., Signori A; Department of Health Sciences - Section of Biostatistics University of Genoa, Italy., Cepparulo S; Ospedale del Mare, (ASL napoli 1), Naples, Italy., Sparaco M; II Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy., Signoriello E; MS Centre, II Division of Neurology, University of Campania Luigi Vanvitelli, Naples, Italy., Maniscalco GT; Department of Neurology and Stroke Unit 'A. Cardarelli Hospital', Naples, Italy., Lanzillo R; Multiple Sclerosis Clinical Care and Research Centre, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University of Naples, Naples, Italy., Morra VB; Multiple Sclerosis Clinical Care and Research Centre, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University of Naples, Naples, Italy., Lus G; MS Centre, II Division of Neurology, University of Campania Luigi Vanvitelli, Naples, Italy., Sormani MP; Department of Health Sciences - Section of Biostatistics University of Genoa, Italy., Lavorgna L; I Division of Neurology, University of Campania Luigi Vanvitelli, Naples, Italy., Bonavita S; II Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy. Electronic address: simona.bonavita@unicampania.it.
Jazyk: angličtina
Zdroj: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2023 Jul; Vol. 75, pp. 104731. Date of Electronic Publication: 2023 Apr 28.
DOI: 10.1016/j.msard.2023.104731
Abstrakt: Introduction: The diagnosis of the progression phase of Multiple Sclerosis (MS) is still retrospective and based on the objectivation of clinical disability accumulation.
Objectives: To assess whether the Patient Reported Outcomes Measures (PROMs) scores predict the occurrence of disease progression within three years of follow-up.
Methods: Observational prospective multicenter study. Stable Relapsing-Remitting MS (RRMS) patients were enrolled. At enrollment, patients completed the following PROMs: Beck Depression Inventory- II, The Treatment Satisfaction Questionnaire for Medications, Medical Outcomes Study Short Form 36- Item (SF36), Fatigue Severity Scale. EDSS was assessed at enrollment and three years later. The outcome measure was defined as the occurrence of confirmed disability progression (CDP) within three years of follow-up. Univariable and multivariable logistic regression models were performed to study the association between the final score of each test and the outcome.
Results: SF36-Physical Functioning (SF36-PF) was the only independent variable associated with the outcome. The ROC curve analysis determined a score of 77.5 at SF36-PF as the cut-off point identifying patients experiencing CDP within three years of follow-up [AUC: 0.66 (95% CI: 0.56-0.75)].
Conclusions: RRMS patients scoring higher (>77.5) at SF36-PF subscale have a higher likelihood to experience CDP within the next three years.
Competing Interests: Declaration of Competing Interest The authors declare no competing interests for this work.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: