Changes in Secretion of the Thyroid and Pituitary Glands with a Gradual Decrease in Deuterium Body Content.

Autor: Yaglova NV; Laboratory of Endocrine System Development, A. P. Avtsyn Research Institute of Human Morphology, , A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia. yaglova@mail.ru., Obernikhin SS; Laboratory of Endocrine System Development, A. P. Avtsyn Research Institute of Human Morphology, , A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia., Timokhina EP; Laboratory of Endocrine System Development, A. P. Avtsyn Research Institute of Human Morphology, , A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia., Yaglov VV; Laboratory of Endocrine System Development, A. P. Avtsyn Research Institute of Human Morphology, , A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia., Nazimova SV; Laboratory of Endocrine System Development, A. P. Avtsyn Research Institute of Human Morphology, , A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Apr; Vol. 174 (6), pp. 797-800. Date of Electronic Publication: 2023 May 09.
DOI: 10.1007/s10517-023-05792-4
Abstrakt: We studied changes in the secretion of thyroid hormones and pituitary thyroid-stimulating hormone (TSH) in young mature male Wistar rats during gradual decrease in deuterium body content. The rats received deuterium-depleted water ([D]=10 ppm) instead of tap water for 21 days. As soon as after 1 day, an increase in the secretion of thyroid hormones was recorded. On day 14, secondary hypothyroidism due to a sharp decrease in TSH secretion by the pituitary gland was found. By day 21, secretion of the thyroid hormones increased, and the reciprocal dependence between the concentrations of thyroid hormones and TSH was restored. Thus, the thyroid gland showed a higher sensitivity to a decrease in the deuterium content in the body than the hypothalamic-pituitary complex. The second difference was in type of response: activation of the secretory processes in the thyroid gland and a transient decrease in the secretory activity of pituitary gland thyrotropes to a decrease in deuterium content.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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