Overview of human B-cell development and antibody deficiencies.

Autor: Nandiwada SL; The Texas Children's Hospital, Section of Immunology, Allergy, and Retrovirology, Baylor College of Medicine, Houston, TX, United States. Electronic address: sara.nandiwada@bcm.edu.
Jazyk: angličtina
Zdroj: Journal of immunological methods [J Immunol Methods] 2023 Aug; Vol. 519, pp. 113485. Date of Electronic Publication: 2023 May 05.
DOI: 10.1016/j.jim.2023.113485
Abstrakt: B cells are a key component of the humoral (antibody-mediated) immune response which is responsible for defense against a variety of pathogens. Here we provide an overview of the current understanding of B cell development and function and briefly describe inborn errors of immunity associated with B cell development defects which can manifest as immune deficiency, malignancy, autoimmunity, or allergy. The knowledge and application of B cell biology are essential for laboratory evaluation and clinical assessment of these B cell disorders.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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