Multifactor Dimensionality Reduction Analysis to Evaluate the Association of Dopamine Beta-Hydroxylase (DΒH) Polymorphisms with Susceptibility to Dementia (SADEM Study).

Autor: Juárez-Cedillo T; Unidad de Investigación en Epidemiología y en Servicios de Salud Área Envejecimiento, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuahutemoc 330. Col. Doctores. C.P.06720, Mexico City, Mexico. terezillo@exalumno.unam.mx.; Unidad de Investigación en Epidemiología Clínica, Hospital General Regional No 1 Carlos Mcgregor Sánchez Navarro, Gabriel Mancera 222 Esq. Xola, Col. Del Valle, Del. Benito Juárez, 03100, Ciudad de Mexico, Mexico. terezillo@exalumno.unam.mx., Martínez-Rodríguez N; Epidemiology, Endocrinology and Nutrition Research Unit, Hospital Infantil de México Federico Gomez, Ministry of Health (SSA), Mexico City, Mexico., Fragoso JM; Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico., Islas-Pérez V; Universidad Nacional Autónoma de México, Mexico City, Mexico., López-Martínez A; Universidad Nacional Autónoma de México, Mexico City, Mexico., Valle-Medina A; Sección de Estudios de Posgrado E Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico.
Jazyk: angličtina
Zdroj: Molecular neurobiology [Mol Neurobiol] 2023 Aug; Vol. 60 (8), pp. 4731-4737. Date of Electronic Publication: 2023 May 06.
DOI: 10.1007/s12035-023-03367-y
Abstrakt: Dementia is a multifactorial disease in which environmental, lifestyle, and genetic factors intervene. Population studies have been used in looking for the susceptibility genes for this disease. Since the activity of dopamine b hydroxylase (DβH) is reduced in the hippocampus and neocortex in the brain, changes in the physiological status of dopamine have been reported in Alzheimer's disease (AD) induced by this enzyme. Therefore, DBH polymorphisms have been associated with susceptibility to some neurological diseases such as AD, but few studies have investigated the relationship between these polymorphisms with other types of dementia, especially in Mexican populations. The aim of this study was to evaluate the association between single-nucleotide polymorphism (SNP) in the dopamine b-hydroxylase (DBH gene (rs1611115) and their interactions with environmental factors and the dementia risk. We examined the genotype of the gene DBH (rs1611115) polymorphism in patients with dementia and healthy. The interaction and the impact of DBH (rs1611115) polymorphism on dementia were examined through multifactor dimensionality reduction (MDR) analysis, and the results were verified by the Chi-square test. Hardy-Weinberg equilibrium (HWE) was also checked by the Chi-square test. The relative risk was expressed by odds ratio (OR) and 95%. A total of 221 dementia patients and 534 controls met the inclusion criteria of MDR analyses. The results of the MDR analysis showed that the development of dementia was positively correlated with interaction between the TT genotype of the DBH1 locus rs1611115 TT and diabetes, hypertension, and alcohol consumption (OR = 6.5: 95% CI = 4.5-9.5), originating further cognitive damage. These findings provide insight into the positive correlation between the metabolism and cardiovascular disorders and the presence of the T allele by means of a recessive model of DBH rs1611115 polymorphism with the suspensibility of dementia.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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