Evaluation of Antidiabetic Activity of Oxadiazole Derivative in Rats.

Autor: Qazi AI; Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, Punjab, Pakistan., Ahmad B; Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, Punjab, Pakistan., Sahibzada MUK; Department of Pharmacy, The Sahara College Narowal, Narowal, Punjab, Pakistan., Anwar F; Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, Punjab, Pakistan., Khusro A; Centre for Research and Development, Department of Biotechnology, Hindustan College of Arts & Science, Padur, OMR, Chennai 603103, India., Alhumaydhi FA; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia., Mohamed AA; Department of Forensic Medicine and Toxicology, Zagazig University, Zagazig 44511, Egypt., Mostafa-Hedeab G; Pharmacology Department & Health Research Unit, Medical College, Jouf University, Saudi Arabia., Emran TB; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh.; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.
Jazyk: angličtina
Zdroj: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2023 Apr 25; Vol. 2023, pp. 1141554. Date of Electronic Publication: 2023 Apr 25 (Print Publication: 2023).
DOI: 10.1155/2023/1141554
Abstrakt: The oxadiazole ring has long been used for the treatment of several diseases. This study aimed to analyze the antihyperglycemic and antioxidant roles of the 1,3,4-oxadiazole derivative with its toxicity. Diabetes was induced through intraperitoneal administration of alloxan monohydrate at 150 mg/kg in rats. Glimepiride and acarbose were used as standards. Rats were divided into groups of normal control, disease control, standard, and diabetic rats (treated with 5, 10, and 15 mg/kg of 1,3,4-oxadiazole derivative). After 14 days of oral administration of 1,3,4-oxadiazole derivatives (5, 10, and 15 mg/kg) to the diabetic group, the blood glucose level, body weight, glycated hemoglobin (HbA1c), insulin level, antioxidant effect, and histopathology of the pancreas were performed. The toxicity was measured by estimating liver enzyme, renal function, lipid profile, antioxidative effect, and liver and kidney histopathological study. The blood glucose and body weight were measured before and after treatment. Alloxan significantly increased blood glucose levels, HbA1c, alanine transaminase, aspartate aminotransferase, urea, cholesterol, triglycerides, and creatinine. In contrast, body weight, insulin level, and antioxidant factors were reduced compared to the normal control group. Treatment with oxadiazole derivatives showed a significant reduction in blood glucose levels, HbA1c, alanine transaminase, aspartate aminotransferase, urea, cholesterol, triglycerides, and creatinine as compared to the disease control group. The 1,3,4-oxadiazole derivative significantly improved body weight, insulin level, and antioxidant factors compared to the disease control group. In conclusion, the oxadiazole derivative showed potential antidiabetic activity and indicated its potential as a therapeutic.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2023 Adil Iqbal Qazi et al.)
Databáze: MEDLINE
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