Device-measured sitting time and musculoskeletal pain in adults with normal glucose metabolism, prediabetes and type 2 diabetes-The Maastricht Study.

Autor: Dzakpasu FQS; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.; Physical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Koster A; Department of Social Medicine, Maastricht University, Maastricht, the Netherlands.; CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands., Owen N; Physical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Centre for Urban Transitions, Swinburne University of Technology, Melbourne, Victoria, Australia., Galan BE; Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands.; Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands., Carver A; National Centre for Healthy Ageing, Peninsula Clinical School, Monash University, Frankston, Victoria, Australia., Brakenridge CJ; Physical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Active Life Lab, South-Eastern Finland University of Applied Sciences, Mikkeli, Finland., Boonen A; CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands.; Division of Rheumatology, Department of Internal Medicine, Maastricht University Medical Centre+, Maastricht, the Netherlands., Bosma H; Department of Social Medicine, Maastricht University, Maastricht, the Netherlands.; CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands., Dagnelie PC; Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands., Eussen SJPM; CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands.; Department of Epidemiology, Maastricht University, Maastricht, the Netherlands., Sethi P; Physical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Stehouwer CDA; Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands., Schaper NC; CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands.; Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands.; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands., Dunstan DW; Physical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 May 04; Vol. 18 (5), pp. e0285276. Date of Electronic Publication: 2023 May 04 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0285276
Abstrakt: Background: Detrimental associations of sedentary behaviour (time spent sitting) with musculoskeletal pain (MSP) conditions have been observed. However, findings on those with, or at risk of, type 2 diabetes (T2D) have not been reported. We examined the linear and non-linear associations of device-measured daily sitting time with MSP outcomes according to glucose metabolism status (GMS).
Methods: Cross-sectional data from 2827 participants aged 40-75 years in the Maastricht Study (1728 with normal glucose metabolism (NGM); 441 with prediabetes; 658 with T2D), for whom valid data were available on activPAL-derived daily sitting time, MSP [neck, shoulder, low back, and knee pain], and GMS. Associations were examined by logistic regression analyses, adjusted serially for relevant confounders, including moderate-to-vigorous intensity physical activity (MVPA) and body mass index (BMI). Restricted cubic splines were used to further examine non-linear relationships.
Results: The fully adjusted model (including BMI, MVPA, and history of cardiovascular disease) showed daily sitting time to be significantly associated with knee pain in the overall sample (OR = 1.07, 95%CI: 1.01-1.12) and in those with T2D (OR = 1.11, 95%CI: 1.00-1.22); this was not statistically significant in those with prediabetes (OR = 1.04, 95%CI: 0.91-1.18) or NGM (OR = 1.05, 95%CI: 0.98-1.13). There were no statistically significant associations between daily sitting time and neck, shoulder, or low back pain in any of the models. Furthermore, the non-linear relationships were statistically non-significant.
Conclusion: Among middle-aged and older adults with T2D, daily sitting time was significantly associated with higher odds of knee pain, but not with neck, shoulder, or low back pain. No significant association was observed in those without T2D for neck, shoulder, low back, or knee pain. Future studies, preferably those utilising prospective designs, could examine additional attributes of daily sitting (e.g., sitting bouts and domain-specific sitting time) and the potential relationships of knee pain with mobility limitations.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Dzakpasu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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