Skeletal muscle omics signatures in cancer cachexia: perspectives and opportunities.
| Autor: | Gilmore LA; Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, USA., Parry TL; Department of Kinesiology, University of North Carolina Greensboro, Greensboro, NC, USA., Thomas GA; Department of Kinesiology, Pennsylvania State University, University Park, PA, USA., Khamoui AV; Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL, USA.; Institute for Human Health and Disease Intervention, Florida Atlantic University, Jupiter, FL, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the National Cancer Institute. Monographs [J Natl Cancer Inst Monogr] 2023 May 04; Vol. 2023 (61), pp. 30-42. |
| DOI: | 10.1093/jncimonographs/lgad006 |
| Abstrakt: | Cachexia is a life-threatening complication of cancer that occurs in up to 80% of patients with advanced cancer. Cachexia reflects the systemic consequences of cancer and prominently features unintended weight loss and skeletal muscle wasting. Cachexia impairs cancer treatment tolerance, lowers quality of life, and contributes to cancer-related mortality. Effective treatments for cancer cachexia are lacking despite decades of research. High-throughput omics technologies are increasingly implemented in many fields including cancer cachexia to stimulate discovery of disease biology and inform therapy choice. In this paper, we present selected applications of omics technologies as tools to study skeletal muscle alterations in cancer cachexia. We discuss how comprehensive, omics-derived molecular profiles were used to discern muscle loss in cancer cachexia compared with other muscle-wasting conditions, to distinguish cancer cachexia from treatment-related muscle alterations, and to reveal severity-specific mechanisms during the progression of cancer cachexia from early toward severe disease. (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.) |
| Databáze: | MEDLINE |
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