| Autor: |
Rodríguez-Grande C, Estévez A, Palomino-Cabrera R, Molero-Salinas A, Peñas-Utrilla D, Herranz M, Sanz-Pérez A, Alcalá L, Veintimilla C, Catalán P, Martínez-Laperche C, Alonso R, Muñoz P, Pérez-Lago L, de Viedma DG |
| Jazyk: |
angličtina |
| Zdroj: |
Emerging infectious diseases [Emerg Infect Dis] 2023 Jun; Vol. 29 (6), pp. 1154-1161. Date of Electronic Publication: 2023 May 02. |
| DOI: |
10.3201/eid2906.221696 |
| Abstrakt: |
Centers for Disease Control and Prevention guidelines consider SARS-CoV-2 reinfection when sequential COVID-19 episodes occur >90 days apart. However, genomic diversity acquired over recent COVID-19 waves could mean previous infection provides insufficient cross-protection. We used genomic analysis to assess the percentage of early reinfections in a sample of 26 patients with 2 COVID-19 episodes separated by 20-45 days. Among sampled patients, 11 (42%) had reinfections involving different SARS-CoV-2 variants or subvariants. Another 4 cases were probable reinfections; 3 involved different strains from the same lineage or sublineage. Host genomic analysis confirmed the 2 sequential specimens belonged to the same patient. Among all reinfections, 36.4% involved non-Omicron, then Omicron lineages. Early reinfections showed no specific clinical patterns; 45% were among unvaccinated or incompletely vaccinated persons, 27% were among persons <18 years of age, and 64% of patients had no risk factors. Time between sequential positive SARS-CoV-2 PCRs to consider reinfection should be re-evaluated. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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