Insights into oral microbiome and colorectal cancer - on the way of searching new perspectives.

Autor:	Kudra A; Scientific Circle of Studies Regarding Personalized Medicine Associated with Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland., Muszyński D; Scientific Circle of Studies Regarding Personalized Medicine Associated with Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland., Sobocki BK; Scientific Circle of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland., Atzeni A; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.; Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició, Reus, Spain.; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain., Carbone L; Department of Medicine Surgery and Neuroscience, University of Siena, Siena, Italy., Kaźmierczak-Siedlecka K; Department of Medical Laboratory Diagnostics - Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdansk, Poland., Połom K; Department of Surgical Oncology, Medical University of Gdansk, Gdansk, Poland., Kalinowski L; Department of Medical Laboratory Diagnostics - Fahrenheit Biobank BBMRI.pl, Medical University of Gdansk, Gdansk, Poland.; BioTechMed Centre, Department of Mechanics of Materials and Structures, University of Technology, Gdansk, Poland.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Apr 12; Vol. 13, pp. 1159822. Date of Electronic Publication: 2023 Apr 12 (Print Publication: 2023).
DOI:	10.3389/fcimb.2023.1159822
Abstrakt:	Microbiome is a keystone polymicrobial community that coexist with human body in a beneficial relationship. These microorganisms enable the human body to maintain homeostasis and take part in mechanisms of defense against infection and in the absorption of nutrients. Even though microbiome is involved in physiologic processes that are beneficial to host health, it may also cause serious detrimental issues. Additionally, it has been proven that bacteria can migrate to other human body compartments and colonize them even although significant structural differences with the area of origin exist. Such migrations have been clearly observed when the causes of genesis and progression of colorectal cancer (CRC) have been investigated. It has been demonstrated that the oral microbiome is capable of penetrating into the large intestine and cause impairments leading to dysbiosis and stimulation of cancerogenic processes. The main actors of such events seem to be oral pathogenic bacteria belonging to the red and orange complex (regarding classification of bacteria in the context of periodontal diseases), such as Porphyromonas gingivalis and Fusobacterium nucleatum respectively, which are characterized by significant amount of cancerogenic virulence factors. Further examination of oral microbiome and its impact on CRC may be crucial on early detection of this disease and would allow its use as a precise non-invasive biomarker. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Kudra, Muszyński, Sobocki, Atzeni, Carbone, Kaźmierczak-Siedlecka, Połom and Kalinowski.)
Databáze:	MEDLINE
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