Hepatobiliary system and intestinal injury in new coronavirus infection (COVID-19): A retrospective study.

Autor:	Kozlov KV; Department of Infectious Disease, Military Medical Academy Named After SM. Kirov, Saint-Petersburg 194044, Russia., Zhdanov KV; Department of Infectious Disease, Military Medical Academy Named After SM. Kirov, Saint-Petersburg 194044, Russia., Ratnikova AK; Department of Admission, Federal State Budgetary Institution 'North-West District Scientific and Clinical Center Named After LG. Sokolov Federal Medical and Biological Agency', Saint-Petersburg 194291, Russia., Ratnikov VA; Department of Roentgenology, Federal State Budgetary Institution 'North-West District Scientific and Clinical Center Named After LG. Sokolov Federal Medical and Biological Agency', Saint-Petersburg 194291, Russia., Tishkov AV; Department of Physics, Mathematics and Informatics, FSBEI HE IP. Pavlov SPbSMU MOH Russia, Saint-Petersburg 197022, Russia., Grinevich V; 2nd Department of Therapy (Advanced Medical Education), Military Medical Academy Named After SM. Kirov, Saint-Petersburg 194044, Russia., Kravchuk YA; Department of Infectious Disease, Military Medical Academy Named After SM. Kirov, Saint-Petersburg 194044, Russia., Miklush PI; Department of Infectious Disease, Military Medical Academy Named After SM. Kirov, Saint-Petersburg 194044, Russia., Nikiforova PO; Department of Infectious Disease, Military Medical Academy Named After SM. Kirov, Saint-Petersburg 194044, Russia., Gordienko VV; Department of Infectious Disease, Military Medical Academy Named After SM. Kirov, Saint-Petersburg 194044, Russia. ivanovavmeda@gmail.com., Popov AF; School of Medicine, Far Eastern Federal University, Vladivostok 690922, Russia., Andryukov BG; School of Medicine, Far Eastern Federal University, Vladivostok 690922, Russia.
Jazyk:	angličtina
Zdroj:	World journal of clinical cases [World J Clin Cases] 2023 Apr 06; Vol. 11 (10), pp. 2226-2236.
DOI:	10.12998/wjcc.v11.i10.2226
Abstrakt:	Background: An important area of effective control of the coronavirus disease 19 (COVID-19) pandemic is the study of the pathogenic features of severe acute respiratory syndrome coronavirus 2 infection, including those based on assessing the state of the intestinal microbiota and permeability. Aim: To study the clinical features of the new COVID-19 in patients with mild and moderate severity at the stage of hospitalization, to determine the role of hepatobiliary injury, intestinal permeability disorders, and changes in the qualitative and quantitative composition of the microbiota in the development of systemic inflammation in patients with COVID-19. Methods: The study was performed in 80 patients with COVID-19, with an average age of 45 years, 19 of whom had mild disease, and 61 had moderate disease severity. The scope of the examination included traditional clinical, laboratory, biochemical, instrumental, and radiation studies, as well as original methods for studying microbiota and intestinal permeability. Results: The clinical course of COVID-19 was studied, and the clinical and biochemical features, manifestations of systemic inflammation, and intestinal microbiome changes in patients with mild and moderate severity were identified. Intestinal permeability characteristics against the background of COVID-19 were evaluated by measuring levels of proinflammatory cytokines, insulin, faecal calprotectin, and zonulin. Conclusion: This study highlights the role of intestinal permeability and microbiota as the main drivers of gastroenterological manifestations and increased COVID-19 severity. Competing Interests: Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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