Microbiota from young mice counteracts selective age-associated behavioral deficits.

Autor: Boehme M; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Guzzetta KE; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Bastiaanssen TFS; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., van de Wouw M; APC Microbiome Ireland, University College Cork, Cork, Ireland., Moloney GM; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Gual-Grau A; APC Microbiome Ireland, University College Cork, Cork, Ireland., Spichak S; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Olavarría-Ramírez L; APC Microbiome Ireland, University College Cork, Cork, Ireland., Fitzgerald P; APC Microbiome Ireland, University College Cork, Cork, Ireland., Morillas E; APC Microbiome Ireland, University College Cork, Cork, Ireland., Ritz NL; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Jaggar M; APC Microbiome Ireland, University College Cork, Cork, Ireland., Cowan CSM; APC Microbiome Ireland, University College Cork, Cork, Ireland., Crispie F; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland., Donoso F; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland., Halitzki E; APC Microbiome Ireland, University College Cork, Cork, Ireland., Neto MC; APC Microbiome Ireland, University College Cork, Cork, Ireland., Sichetti M; APC Microbiome Ireland, University College Cork, Cork, Ireland., Golubeva AV; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Fitzgerald RS; APC Microbiome Ireland, University College Cork, Cork, Ireland.; School of Microbiology, University College Cork, Cork, Ireland., Claesson MJ; APC Microbiome Ireland, University College Cork, Cork, Ireland.; School of Microbiology, University College Cork, Cork, Ireland., Cotter PD; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland., O'Leary OF; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Dinan TG; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland., Cryan JF; APC Microbiome Ireland, University College Cork, Cork, Ireland. j.cryan@ucc.ie.; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. j.cryan@ucc.ie.
Jazyk: angličtina
Zdroj: Nature aging [Nat Aging] 2021 Aug; Vol. 1 (8), pp. 666-676. Date of Electronic Publication: 2021 Aug 09.
DOI: 10.1038/s43587-021-00093-9
Abstrakt: The gut microbiota is increasingly recognized as an important regulator of host immunity and brain health. The aging process yields dramatic alterations in the microbiota, which is linked to poorer health and frailty in elderly populations. However, there is limited evidence for a mechanistic role of the gut microbiota in brain health and neuroimmunity during aging processes. Therefore, we conducted fecal microbiota transplantation from either young (3-4 months) or old (19-20 months) donor mice into aged recipient mice (19-20 months). Transplant of a microbiota from young donors reversed aging-associated differences in peripheral and brain immunity, as well as the hippocampal metabolome and transcriptome of aging recipient mice. Finally, the young donor-derived microbiota attenuated selective age-associated impairments in cognitive behavior when transplanted into an aged host. Our results reveal that the microbiome may be a suitable therapeutic target to promote healthy aging.
(© 2021. Springer Nature America, Inc.)
Databáze: MEDLINE
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