Catechin from Anonna senegalensis is a Potential Inhibitor of Erectile Dysfunction: Implication for Its Use in Male Sexual Enhancement.

Autor: Folawiyo MA; Faculty of Basic Medical Sciences, Department of Physiology, Ladoke Akintola University of Technology, Ogbomosho, P.M.B. 4000, Nigeria.; Faculty of Basic Medical Sciences, College of Medicine, Ekiti State University, Ado-Ekiti, Nigeria.; Molecular Biology and Molecular Simulation Center (Mols &Sims), Ado-Ekiti, Nigeria., Omotuyi IO; Molecular Biology and Molecular Simulation Center (Mols &Sims), Ado-Ekiti, Nigeria.; Institute for Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, Ado-Ekiti, Nigeria., Ajao FO; Faculty of Basic Medical Sciences, College of Medicine, Ekiti State University, Ado-Ekiti, Nigeria., Besong E; Faculty of Basic Medical Sciences, Department of Physiology, Ebonyi State University, Abakaliki, P.M.B. 053, Nigeria., Adelusi TI; Computational Biology and Drug Discovery Laboratory, Faculty of Basic Medical Sciences, Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomosho, P.M.B. 4000, Nigeria., Ajayi AF; Faculty of Basic Medical Sciences, Department of Physiology, Ladoke Akintola University of Technology, Ogbomosho, P.M.B. 4000, Nigeria. aajayi22@lautech.edu.ng.
Jazyk: angličtina
Zdroj: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2023 Aug; Vol. 195 (8), pp. 4936-4964. Date of Electronic Publication: 2023 Apr 28.
DOI: 10.1007/s12010-023-04557-z
Abstrakt: Erectile dysfunction (ED) is a major challenge for men. The drugs for its treatment are associated with side effects. Hence, in phytomedicinal research, where Anonna senegalensis (A. senegalensis) is a candidate with abundant phytochemicals possessing various pharmacological properties, but the sex-enhancing phytochemical is elusive in the literature. This study aimed to understand the molecular interaction of its potent molecule mediating male sexual enhancement. A library of 69 compounds from A. senegalensis was docked against the ED-targeted proteins. Sildenafil citrate was used as the reference standard. Thereafter, the lead compound was screened for drug-likeness by applying the Lipinski rule of 5 (RO5), pharmacokinetic properties, and bioactivity using SwissADME and Molinspiration web servers, respectively. The results show catechin as the lead phytochemical compound with a stronger binding affinity for most of the proteins of ED. Also, catechin demonstrates good compliance with the RO5, great pharmacokinetic profiles, and could be said to be a polypharmacological molecule with good bioactivity scores. The research findings unravel the potential of catechin (a phytochemical belonging to the flavonoids class) from A. senegalensis leaf as a potential male sexual enhancement molecule via its high binding affinity for most erectile dysfunction-targeted proteins. They may require further toxicity and therapeutic evaluations in vivo.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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