| Autor: |
Codoñer-Franch P; Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, 46010 Valencia, Spain.; Department of Pediatrics, University Hospital Doctor Peset, Foundation for the Promotion of Health and Bio-Medical Research in the Valencian Region (FISABIO), 46017 Valencia, Spain., Gombert M; Biosciences Division, Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA., Martínez-Raga J; Department of Psychiatry and Clinical Psychology, Hospital Universitario Doctor Peset, University of Valencia, 46017 Valencia, Spain., Cenit MC; Microbial Ecology, Nutrition & Health Research Unit, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), 46980 Valencia, Spain. |
| Abstrakt: |
Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired circadian rhythms are associated with mental disorders. The evening chronotype, which is linked to circadian misalignment, is a risk factor for severe psychiatric symptoms and psychiatric metabolic comorbidities. Resynchronization of circadian rhythms commonly improves psychiatric symptoms. Furthermore, evidence indicates that preventing circadian misalignment may help reduce the risk of psychiatric disorders and the impact of neuro-immuno-metabolic disturbances in psychiatry. The gut microbiota exhibits diurnal rhythmicity, as largely governed by meal timing, which regulates the host's circadian rhythms. Temporal circadian regulation of feeding has emerged as a promising chronotherapeutic strategy to prevent and/or help with the treatment of mental illnesses, largely through the modulation of gut microbiota. Here, we provide an overview of the link between circadian disruption and mental illness. We summarize the connection between gut microbiota and circadian rhythms, supporting the idea that gut microbiota modulation may aid in preventing circadian misalignment and in the resynchronization of disrupted circadian rhythms. We describe diurnal microbiome rhythmicity and its related factors, highlighting the role of meal timing. Lastly, we emphasize the necessity and rationale for further research to develop effective and safe microbiome and dietary strategies based on chrononutrition to combat mental illness. |
