Association of sleep and anaesthesia EEG biomarkers with preoperative MoCA score: A pilot study.

Autor: Touchard C; Department of Anesthesiology and Intensive Care, Lariboisière - Saint Louis Hospitals, Paris, France.; Université Paris Cité, Boulogne-Billancourt, France., Guimard P; Department of Anesthesiology and Intensive Care, Lariboisière - Saint Louis Hospitals, Paris, France.; Université Paris Cité, Boulogne-Billancourt, France., Guessous K; Department of Anesthesiology and Intensive Care, Lariboisière - Saint Louis Hospitals, Paris, France.; Sorbonne Université, Paris, France., Aubin OS; Department of Anesthesiology and Intensive Care, Lariboisière - Saint Louis Hospitals, Paris, France.; Université Paris Cité, Boulogne-Billancourt, France., Levé C; Department of Anesthesiology and Intensive Care, Lariboisière - Saint Louis Hospitals, Paris, France.; Université Paris Cité, Boulogne-Billancourt, France., Joachim J; Department of Anesthesiology and Intensive Care, Lariboisière - Saint Louis Hospitals, Paris, France.; Université Paris Cité, Boulogne-Billancourt, France., Elayeb K; Department of Anesthesiology and Intensive Care, Lariboisière - Saint Louis Hospitals, Paris, France.; Université Paris Cité, Boulogne-Billancourt, France., Mebazaa A; Department of Anesthesiology and Intensive Care, Lariboisière - Saint Louis Hospitals, Paris, France.; Université Paris Cité, Boulogne-Billancourt, France.; Inserm, UMRS-942, Paris Diderot University, Paris, France., Gayat É; Department of Anesthesiology and Intensive Care, Lariboisière - Saint Louis Hospitals, Paris, France.; Université Paris Cité, Boulogne-Billancourt, France.; Inserm, UMRS-942, Paris Diderot University, Paris, France., Mateo J; Department of Anesthesiology and Intensive Care, Lariboisière - Saint Louis Hospitals, Paris, France.; Université Paris Cité, Boulogne-Billancourt, France.; Inserm, UMRS-942, Paris Diderot University, Paris, France., Vallée F; Department of Anesthesiology and Intensive Care, Lariboisière - Saint Louis Hospitals, Paris, France.; Université Paris Cité, Boulogne-Billancourt, France.; Inserm, UMRS-942, Paris Diderot University, Paris, France.; Université Paris-Saclay, Palaiseau, France., Cartailler J; Department of Anesthesiology and Intensive Care, Lariboisière - Saint Louis Hospitals, Paris, France.; Inserm, UMRS-942, Paris Diderot University, Paris, France.
Jazyk: angličtina
Zdroj: Acta anaesthesiologica Scandinavica [Acta Anaesthesiol Scand] 2023 Aug; Vol. 67 (7), pp. 877-884. Date of Electronic Publication: 2023 Apr 25.
DOI: 10.1111/aas.14251
Abstrakt: Introduction: Preoperative cognitive impairments increase the risk of postoperative complications. The electroencephalogram (EEG) could provide information on cognitive vulnerability. The feasibility and clinical relevance of sleep EEG (EEG sleep ) compared to intraoperative EEG (EEG intraop ) in cognitive risk stratification remains to be explored. We investigated similarities between EEG sleep and EEG intraop vis-a-vis preoperative cognitive impairments.
Methods: Pilot study including 27 patients (63 year old [53.5, 70.0]) to whom Montreal cognitive assessment (MoCA) and EEG sleep were administered 1 day before a propofol-based general anaesthesia, in addition to EEG intraop acquisition from depth-of-anaesthesia monitors. Sleep spindles on EEG sleep and intraoperative alpha-band power on EEG intraop were particularly explored.
Results: In total, 11 (41%) patients had a MoCA <25 points. These patients had a significantly lower sleep spindle power on EEG sleep (25 vs. 40 μv 2 /Hz, p = .035) and had a weaker intraoperative alpha-band power on EEG intraop (85 vs. 150 μv 2 /Hz, p = .001) compared to patients with normal MoCA. Correlation between sleep spindle and intraoperative alpha-band power was positive and significant (r = 0.544, p = .003).
Conclusion: Preoperative cognitive impairment appears to be detectable by both EEG sleep and EEG intraop . Preoperative sleep EEG to assess perioperative cognitive risk is feasible but more data are needed to demonstrate its benefit compared to intraoperative EEG.
(© 2023 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.)
Databáze: MEDLINE
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