Plasma metabolomic response to high-carbohydrate meals of differing glycaemic load in overweight women.

Autor: Durainayagam B; Liggins Institute, University of Auckland, Auckland, New Zealand.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London, UK., Mitchell CJ; Liggins Institute, University of Auckland, Auckland, New Zealand.; School of Kinesiology, The University of British Columbia, Vancouver, BC, Canada., Milan AM; Liggins Institute, University of Auckland, Auckland, New Zealand.; Food & Bio-Based Products Group, AgResearch, Palmerston North, New Zealand.; High-Value Nutrition, National Science Challenge, Auckland, New Zealand., Kruger MC; School of Health Sciences, College of Health, Massey University, Palmerston North, New Zealand.; The Riddet Institute, Massey University, Palmerston North, New Zealand., Roy NC; High-Value Nutrition, National Science Challenge, Auckland, New Zealand.; The Riddet Institute, Massey University, Palmerston North, New Zealand.; Department of Human Nutrition, University of Otago, Dunedin, New Zealand., Fraser K; Food & Bio-Based Products Group, AgResearch, Palmerston North, New Zealand.; The Riddet Institute, Massey University, Palmerston North, New Zealand., Cameron-Smith D; Liggins Institute, University of Auckland, Auckland, New Zealand. david.cameronsmith@newcastle.edu.au.; The Riddet Institute, Massey University, Palmerston North, New Zealand. david.cameronsmith@newcastle.edu.au.; Colleges of Health, Medicine and Wellbeing, and Engineering, Science and Environment, The University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. david.cameronsmith@newcastle.edu.au.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2023 Aug; Vol. 62 (5), pp. 2257-2267. Date of Electronic Publication: 2023 Apr 21.
DOI: 10.1007/s00394-023-03151-7
Abstrakt: Background: Metabolomic dysregulation following a meal in overweight individuals with the Metabolic Syndrome (MetS) involves multiple pathways of nutrient storage and oxidation.
Objective: The aim of the current study was to perform an acute cross-over intervention to examine the interactive actions of meal glycaemic load (GL) on the dynamic responses of the plasma metabolome in overweight females.
Methods: Postmenopausal women [63 ± 1.23y; Healthy (n = 20) and MetS (n = 20)] ingested two differing high-carbohydrate test meals (73 g carbohydrate; 51% energy) composed of either low glycemic index (LGI) or high (HGI) foods in a randomised sequence. Plasma metabolome was analysed using liquid chromatography-mass spectrometry (LC-MS).
Results: In the overweight women with MetS, there were suppressed postprandial responses for several amino acids (AAs), including phenylalanine, leucine, valine, and tryptophan, p < 0.05), irrespective of the meal type. Meal GL exerted a limited impact on the overall metabolomic response, although the postprandial levels of alanine were higher with the low GL meal and uric acid was greater following the high GL meal (p < 0.05).
Conclusions: MetS participants exhibited reduced differences in the concentrations of a small set of AAs and a limited group of metabolites implicated in energy metabolism following the meals. However, the manipulation of meal GL had minimal impact on the postprandial metabolome. This study suggests that the GL of a meal is not a major determinant of postprandial response, with a greater impact exerted by the metabolic health of the individual. Trial registration Australia New Zealand Clinical Trials Registry: ACTRN12615001108505 (21/10/2015).
(© 2023. The Author(s).)
Databáze: MEDLINE
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