Decellularized Extracellular Matrix for Tissue Engineering (Review).

Autor:	Isaeva EV; Senior Researcher, Laboratory of Biomaterials and Tissue Constructions; A. Tsyb Меdical Radiological Research Centre - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 10 Zhukova St., Obninsk, 249036, Russia., Beketov EE; Head of the Laboratory of Biomaterials and Tissue Constructions; A. Tsyb Меdical Radiological Research Centre - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 10 Zhukova St., Obninsk, 249036, Russia., Arguchinskaya NV; Junior Researcher, Laboratory of Biomaterials and Tissue Constructions; A. Tsyb Меdical Radiological Research Centre - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 10 Zhukova St., Obninsk, 249036, Russia., Ivanov SА; Director; A. Tsyb Меdical Radiological Research Centre - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 10 Zhukova St., Obninsk, 249036, Russia; Professor, Department of Oncology and Radiology and Nuclear Medicine; Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russia., Shegay PV; Head of the Center of Innovative Radiological and Regenerative Technologies; National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 4 Koroleva St., Obninsk, 249036, Russia., Kaprin АD; Professor, Academician of the Russian Academy of Sciences, General Director; National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 4 Koroleva St., Obninsk, 249036, Russia Head of the Department of Urology and Operative Nephrology with the Course of Oncourology of the Medical Institute; Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russia.
Jazyk:	angličtina
Zdroj:	Sovremennye tekhnologii v meditsine [Sovrem Tekhnologii Med] 2022; Vol. 14 (3), pp. 57-68. Date of Electronic Publication: 2022 May 28.
DOI:	10.17691/stm2022.14.3.07
Abstrakt:	In recent years, decellularized tissues have evolved into a new, full-fledged platform for the creation of tissue-engineered constructions. Extracellular matrix (ECM) of each tissue provides a unique tissue-specific microenvironment for resident cells with the structure and biochemical signaling required for their functioning. The decellularized ECM (dECM) has been established to influence cell differentiation. The review provides recent data on the composition and functions of the ECM, methods for obtaining decellularized tissues, and their application in tissue engineering depending on their physical form (scaffold, powder, or hydrogel). The effect of the matrix source, decellularization and sterilization techniques on dECM composition has been considered. Regulatory mechanisms of cell differentiation by the extracellular matrix are discussed. Differences in the protein composition of the native and decellularized materials are presented. Application of dECM in the bioink composition for regeneration of various tissues using bioprinting technologies is also considered. It has been concluded that successful application of dECM in tissue engineering and regenerative medicine requires a permanent and biologically suitable dECM source, optimized tissue decellularization protocols, improved mechanical properties of dECM-derived bioinks, and prevention of immunological reaction of the organism. Competing Interests: Conflicts of interest. The authors have no conflicts of interest to declare.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu