Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts.
| Autor: | Hammouda MM; Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University Al-Kharj 11942 Saudi Arabia.; Chemistry Department, Faculty of Science, Mansoura University El-Gomhoria Street Mansoura 35516 Egypt elmhammouda@mans.edu.eg., Rashed MM; Toxicology Department, Mansoura Hospital, Faculty of Medicine, Mansoura University El-Gomhoria Street Mansoura 35516 Egypt marwarashed@mans.edu.eg., Elattar KM; Unit of Genetic Engineering and Biotechnology, Faculty of Science, Mansoura University El-Gomhoria Street Mansoura 35516 Egypt khaledelattar2@yahoo.com +20-1010655354., Osman AMA; Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University Al-Kharj 11942 Saudi Arabia.; Chemistry Department, Faculty of Science, Menoufia University Shebin El-Koam Egypt amanyosman812@gmail.com. |
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| Jazyk: | angličtina |
| Zdroj: | RSC advances [RSC Adv] 2023 Apr 14; Vol. 13 (17), pp. 11600-11634. Date of Electronic Publication: 2023 Apr 14 (Print Publication: 2023). |
| DOI: | 10.1039/d3ra00922j |
| Abstrakt: | Nano-catalysts are of special character for the synthesis of organic molecules with high efficiency, and exceptional physicochemical properties. The objective of this study was to present an overview of the literature reports concerning the synthetic strategies supported by nano-catalysts and the biological features of heterocycle-integrated pyridopyrimidine scaffolds. The basic topics include the strategies that were adopted to prepare pyrido[2,3- d ]pyrimidines and pyrido[1,2- a ]pyrimidines. The synthesis of pyrido[2,3- d ]pyrimidines was attained through two-, three-, or four-component reactions. The synthesis of spirocyclic systems, including spiro[indoline-pyridopyrimidine] derivatives and arylation reactions, was investigated. The anticipated mechanisms of the diverse target products, in addition to the preparation of the nanocatalysts, were scrutinized. The privileged antimicrobial characteristics, challenges, literature overview, and future prospectives were consistently investigated. Competing Interests: The authors assert no conflicts of interest. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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