Associations of physical function and body mass index with functional brain networks in community-dwelling older adults.

Autor: Laurienti PJ; Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA. Electronic address: plaurien@wakehealth.edu., Miller ME; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Lyday RG; Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Boyd MC; Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Tanase AD; Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Burdette JH; Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Hugenschmidt CE; Sticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Rejeski WJ; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA., Simpson SL; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Baker LD; Sticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Tomlinson CE; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kritchevsky SB; Sticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2023 Jul; Vol. 127, pp. 43-53. Date of Electronic Publication: 2023 Mar 21.
DOI: 10.1016/j.neurobiolaging.2023.03.008
Abstrakt: Deficits in physical function that occur with aging contribute to declines in quality of life and increased mortality. There has been a growing interest in examining associations between physical function and neurobiology. Whereas high levels of white matter disease have been found in individuals with mobility impairments in structural brain studies, much less is known about the relationship between physical function and functional brain networks. Even less is known about the association between modifiable risk factors such as body mass index (BMI) and functional brain networks. The current study examined baseline functional brain networks in 192 individuals from the Brain Networks and mobility (B-NET) study, an ongoing longitudinal, observational study in community-dwelling adults aged 70 and older. Physical function and BMI were found to be associated with sensorimotor and dorsal attention network connectivity. There was a synergistic interaction such that high physical function and low BMI were associated with the highest network integrity. White matter disease did not modify these relationships. Future work is needed to understand the causal direction of these relationships.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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