The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland: A genomics-based retrospective cohort analysis.

Autor: Pascall DJ; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom.; Joint Universities Pandemic and Epidemiological Research (JUNIPER) Consortium, United Kingdom., Vink E; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom.; NHS Lothian, Edinburgh, United Kingdom., Blacow R; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom.; NHS Greater Glasgow and Clyde, Glasgow, United Kingdom., Bulteel N; NHS Fife, Kirkcaldy, Fife, United Kingdom., Campbell A; NHS Lothian, Edinburgh, United Kingdom., Campbell R; NHS Lothian, Edinburgh, United Kingdom., Clifford S; NHS Lothian, Edinburgh, United Kingdom., Davis C; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom., da Silva Filipe A; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom., El Sakka N; NHS Grampian, Aberdeen, United Kingdom., Fjodorova L; NHS Greater Glasgow and Clyde, Glasgow, United Kingdom., Forrest R; NHS Fife, Kirkcaldy, Fife, United Kingdom., Goldstein E; NHS Greater Glasgow and Clyde, Glasgow, United Kingdom., Gunson R; NHS Greater Glasgow and Clyde, Glasgow, United Kingdom., Haughney J; NHS Greater Glasgow and Clyde, Glasgow, United Kingdom., Holden MTG; Public Health Scotland, Edinburgh, United Kingdom.; School of Medicine, University of St Andrews, St Andrews, Fife, United Kingdom., Honour P; NHS Borders, Melrose, Scottish Borders, United Kingdom., Hughes J; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom., James E; NHS Borders, Melrose, Scottish Borders, United Kingdom., Lewis T; NHS Lothian, Edinburgh, United Kingdom., Lycett S; The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom., MacLean O; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom., McHugh M; NHS Lothian, Edinburgh, United Kingdom., Mollett G; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom.; NHS Greater Glasgow and Clyde, Glasgow, United Kingdom., Onishi Y; NHS Grampian, Aberdeen, United Kingdom., Parcell B; School of Life Sciences, University of Dundee, Dundee, United Kingdom., Ray S; School of Mathematics and Statistics, University of Glasgow, Glasgow, United Kingdom., Robertson DL; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom., Shabaan S; Public Health Scotland, Edinburgh, United Kingdom., Shepherd JG; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom., Smollett K; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom., Templeton K; NHS Lothian, Edinburgh, United Kingdom., Wastnedge E; NHS Lothian, Edinburgh, United Kingdom., Wilkie C; School of Mathematics and Statistics, University of Glasgow, Glasgow, United Kingdom., Williams T; NHS Lothian, Edinburgh, United Kingdom.; Royal Hospital for Children and Young People, University of Edinburgh, Edinburgh, United Kingdom., Thomson EC; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom.; NHS Greater Glasgow and Clyde, Glasgow, United Kingdom.; London School of Hygiene and Tropical Medicine, London, United Kingdom.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Apr 13; Vol. 18 (4), pp. e0284187. Date of Electronic Publication: 2023 Apr 13 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0284187
Abstrakt: Objectives: The SARS-CoV-2 Alpha variant was associated with increased transmission relative to other variants present at the time of its emergence and several studies have shown an association between Alpha variant infection and increased hospitalisation and 28-day mortality. However, none have addressed the impact on maximum severity of illness in the general population classified by the level of respiratory support required, or death. We aimed to do this.
Methods: In this retrospective multi-centre clinical cohort sub-study of the COG-UK consortium, 1475 samples from Scottish hospitalised and community cases collected between 1st November 2020 and 30th January 2021 were sequenced. We matched sequence data to clinical outcomes as the Alpha variant became dominant in Scotland and modelled the association between Alpha variant infection and severe disease using a 4-point scale of maximum severity by 28 days: 1. no respiratory support, 2. supplemental oxygen, 3. ventilation and 4. death.
Results: Our cumulative generalised linear mixed model analyses found evidence (cumulative odds ratio: 1.40, 95% CI: 1.02, 1.93) of a positive association between increased clinical severity and lineage (Alpha variant versus pre-Alpha variants).
Conclusions: The Alpha variant was associated with more severe clinical disease in the Scottish population than co-circulating lineages.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Pascall et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje