Layer-specific stimulations of parvalbumin-positive cortical interneurons in mice entrain brain rhythms to different frequencies.

Autor:	David F; INSERM U1028, UMR5292, UCBL, Lyon Neuroscience Research Center, Neurocampus, 95 boulevard Pinel, Bron 69500, France.; CNRS, Integrative Neuroscience and Cognition Center, Université Paris Cité, 45, rue des Saints-Pères, Paris F-75006, France., Borel M; INSERM U1028, UMR5292, UCBL, Lyon Neuroscience Research Center, Neurocampus, 95 boulevard Pinel, Bron 69500, France., Ayub S; Department of Microsystems Engineering (IMTEK), University of Freiburg, Georges-Koehler-Allee 103D-79110, Freiburg, Germany., Ruther P; Department of Microsystems Engineering (IMTEK), University of Freiburg, Georges-Koehler-Allee 103D-79110, Freiburg, Germany., Gentet LJ; INSERM U1028, UMR5292, UCBL, Lyon Neuroscience Research Center, Neurocampus, 95 boulevard Pinel, Bron 69500, France.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2023 Jun 20; Vol. 33 (13), pp. 8286-8299.
DOI:	10.1093/cercor/bhad114
Abstrakt:	Neocortical interneurons provide inhibition responsible for organizing neuronal activity into brain oscillations that subserve cognitive functions such as memory, attention, or prediction. However, the interneuronal contribution to the entrainment of neocortical oscillations within and across different cortical layers was not described. Here, using layer-specific optogenetic stimulations with micro-Light-Emitting Diode arrays, directed toward parvalbumin-expressing (PV) interneurons in non-anesthetized awake mice, we found that supragranular layer stimulations of PV neurons were most efficient at entraining supragranular local field potential (LFP) oscillations at gamma frequencies (γ: 25-80 Hz), whereas infragranular layer stimulation of PV neurons better entrained the LFP at delta (δ: 2-5 Hz) and theta (θ: 6-10 Hz) frequencies. At the level of neuronal action potential activity, we observed that supragranular neurons better followed the imposed PV stimulation rhythm than their infragranular counterparts at most frequencies when the stimulation was delivered in their respective layer. Moreover, the neuronal entrainment evoked by local stimulation could propagate across layers, though with a lesser impact when the stimulation occurs in deep layers, suggesting a direction-specific laminar propagation. These results establish a layer-based framework for oscillations to entrain the primary somatosensory cortex in awake conditions. (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu