Immunological impact of cytokines on the chikungunya virus pathophysiology: A literature narrative review.

Autor: Nunes JAL; Postgraduate Program in Parasitic Biology of the Amazon, Center for Biological and Health Sciences, University of the State of Pará, Belém, Pará, Brazil.; Department of Arbovirology and Hemorrhagic Fever, Instituto Evandro Chagas, Ministry of Health, Ananindeua, Pará, Brazil., Sousa JR; Postgraduate Program in Parasitic Biology of the Amazon, Center for Biological and Health Sciences, University of the State of Pará, Belém, Pará, Brazil.; Department of Arbovirology and Hemorrhagic Fever, Instituto Evandro Chagas, Ministry of Health, Ananindeua, Pará, Brazil., Smith VC; Postgraduate Program in Virology, Instituto Evandro Chagas, Ananindeua, Pará, Brazil., Quaresma JS; Postgraduate Program in Parasitic Biology of the Amazon, Center for Biological and Health Sciences, University of the State of Pará, Belém, Pará, Brazil.; Postgraduate Program in Virology, Instituto Evandro Chagas, Ananindeua, Pará, Brazil., Vasconcelos PFDC; Postgraduate Program in Parasitic Biology of the Amazon, Center for Biological and Health Sciences, University of the State of Pará, Belém, Pará, Brazil.; Department of Arbovirology and Hemorrhagic Fever, Instituto Evandro Chagas, Ministry of Health, Ananindeua, Pará, Brazil.; Postgraduate Program in Virology, Instituto Evandro Chagas, Ananindeua, Pará, Brazil., Chiang JO; Postgraduate Program in Parasitic Biology of the Amazon, Center for Biological and Health Sciences, University of the State of Pará, Belém, Pará, Brazil.; Department of Arbovirology and Hemorrhagic Fever, Instituto Evandro Chagas, Ministry of Health, Ananindeua, Pará, Brazil.
Jazyk: angličtina
Zdroj: Reviews in medical virology [Rev Med Virol] 2023 Jul; Vol. 33 (4), pp. e2441. Date of Electronic Publication: 2023 Apr 05.
DOI: 10.1002/rmv.2441
Abstrakt: The chikungunya virus (CHIKV) is a member of the genus Alphavirus, family Togaviridae. CHIKV causes an acute systemic febrile condition, accompanied by severe polyarthralgia, intense muscle pain, and maculopapular exanthema, which may still occur in many patients. In rare cases, unusual symptoms may occur, eventually worsening the condition and resulting in a fatal outcome. It is a single-stranded, non-segmented RNA virus with a genome of approximately 11,805 nucleotides that organises a genetic and molecular chain that encodes non-structural proteins (nsP1, nsP2, nsP3, nsP4) and structural proteins (E3, E2, 6K, and E1). The fundamental role of immune response in the evolution of the disease is known. Understanding the role of immune response in the pathogenesis of CHIKV infection is challenging. In this context, innate and adaptive immune responses establish a connective interface that induces the production of various mediators that modulate the strategy of inhibiting viral replication. However, the immune escape articulated by the virus indicates that the action of pro-and anti-inflammatory cytokines contributes to the worsening of the disease and potentiates tissue damage with joint involvement. In this review, we discuss the role of the primary pro-and anti-inflammatory cytokines in the immunopathological processes of chikungunya fever.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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