Research progress toward the influence of mosquito salivary proteins on the transmission of mosquito-borne viruses.

Autor: Wang ZY; Tsinghua University-Peking University Joint Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China.; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China., Nie KX; Department of Pathogen Biology, School of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China., Niu JC; Tsinghua University-Peking University Joint Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China.; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China., Cheng G; Tsinghua University-Peking University Joint Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China.; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.
Jazyk: angličtina
Zdroj: Insect science [Insect Sci] 2024 Jun; Vol. 31 (3), pp. 663-673. Date of Electronic Publication: 2023 Apr 05.
DOI: 10.1111/1744-7917.13193
Abstrakt: Mosquito-borne viruses (MBVs) are a large class of viruses transmitted mainly through mosquito bites, including dengue virus, Zika virus, Japanese encephalitis virus, West Nile virus, and chikungunya virus, which pose a major threat to the health of people around the world. With global warming and extended human activities, the incidence of many MBVs has increased significantly. Mosquito saliva contains a variety of bioactive protein components. These not only enable blood feeding but also play a crucial role in regulating local infection at the bite site and the remote dissemination of MBVs as well as in remodeling the innate and adaptive immune responses of host vertebrates. Here, we review the physiological functions of mosquito salivary proteins (MSPs) in detail, the influence and the underlying mechanism of MSPs on the transmission of MBVs, and the current progress and issues that urgently need to be addressed in the research and development of MSP-based MBV transmission blocking vaccines.
(© 2023 The Authors. Insect Science published by John Wiley & Sons Australia, Ltd on behalf of Institute of Zoology, Chinese Academy of Sciences.)
Databáze: MEDLINE
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