Hippocampal spatio-predictive cognitive maps adaptively guide reward generalization.

Autor: Garvert MM; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. mona.garvert@gmail.com.; Max Planck Research Group NeuroCode, Max Planck Institute for Human Development, Berlin, Germany. mona.garvert@gmail.com.; Max Planck Institute for Biological Cybernetics, Tübingen, Germany. mona.garvert@gmail.com., Saanum T; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany., Schulz E; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany., Schuck NW; Max Planck Research Group NeuroCode, Max Planck Institute for Human Development, Berlin, Germany.; Max Planck Institute for Biological Cybernetics, Tübingen, Germany.; Institute of Psychology, Universität Hamburg, Hamburg, Germany., Doeller CF; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. doeller@cbs.mpg.de.; Kavli Institute for Systems Neuroscience, Centre for Neural Computation, The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Jebsen Centre for Alzheimer's Disease NTNU, Trondheim, Norway. doeller@cbs.mpg.de.; Wilhelm Wundt Institute of Psychology, Leipzig University, Leipzig, Germany. doeller@cbs.mpg.de.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2023 Apr; Vol. 26 (4), pp. 615-626. Date of Electronic Publication: 2023 Apr 03.
DOI: 10.1038/s41593-023-01283-x
Abstrakt: The brain forms cognitive maps of relational knowledge-an organizing principle thought to underlie our ability to generalize and make inferences. However, how can a relevant map be selected in situations where a stimulus is embedded in multiple relational structures? Here, we find that both spatial and predictive cognitive maps influence generalization in a choice task, where spatial location determines reward magnitude. Mirroring behavior, the hippocampus not only builds a map of spatial relationships but also encodes the experienced transition structure. As the task progresses, participants' choices become more influenced by spatial relationships, reflected in a strengthening of the spatial map and a weakening of the predictive map. This change is driven by orbitofrontal cortex, which represents the degree to which an outcome is consistent with the spatial rather than the predictive map and updates hippocampal representations accordingly. Taken together, this demonstrates how hippocampal cognitive maps are used and updated flexibly for inference.
(© 2023. The Author(s).)
Databáze: MEDLINE
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