The risk of hypogonadism after testicular sperm extraction in men with various types of azoospermia: a prospective cohort study.

Autor: Eliveld J; Amsterdam UMC location University of Amsterdam, Reproductive Biology Laboratory, Center for Reproductive Medicine, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development, Amsterdam, The Netherlands., van der Bles I; Amsterdam UMC location University of Amsterdam, Reproductive Biology Laboratory, Center for Reproductive Medicine, Amsterdam, The Netherlands., van Wely M; Amsterdam UMC location University of Amsterdam, Reproductive Biology Laboratory, Center for Reproductive Medicine, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development, Amsterdam, The Netherlands., Meißner A; Amsterdam Reproduction and Development, Amsterdam, The Netherlands., Soufan AT; Amsterdam UMC location University of Amsterdam, Reproductive Biology Laboratory, Center for Reproductive Medicine, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development, Amsterdam, The Netherlands., Heijboer AC; Amsterdam UMC location University of Amsterdam Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam, The Netherlands.; Amsterdam Gastroenterology and Metabolism, Amsterdam, The Netherlands., Repping S; Amsterdam UMC location University of Amsterdam, Reproductive Biology Laboratory, Center for Reproductive Medicine, Amsterdam, The Netherlands., van der Veen F; Amsterdam UMC location University of Amsterdam, Reproductive Biology Laboratory, Center for Reproductive Medicine, Amsterdam, The Netherlands., van Pelt AMM; Amsterdam UMC location University of Amsterdam, Reproductive Biology Laboratory, Center for Reproductive Medicine, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development, Amsterdam, The Netherlands.. Electronic address: a.m.vanpelt@amsterdamumc.nl.
Jazyk: angličtina
Zdroj: Reproductive biomedicine online [Reprod Biomed Online] 2023 Jun; Vol. 46 (6), pp. 973-981. Date of Electronic Publication: 2023 Feb 10.
DOI: 10.1016/j.rbmo.2023.02.003
Abstrakt: Research Question: What is the risk of hypogonadism in men with obstructive azoospermia, non-obstructive azoospermia (NOA) or Klinefelter syndrome after testicular sperm extraction (TESE)?
Design: This prospective longitudinal cohort study was carried out between 2007 and 2015.
Results: Around 36% of men with Klinefelter syndrome, 4% of men with obstructive azoospermia and 3% of men with NOA needed testosterone replacement therapy (TRT). Klinefelter syndrome was strongly associated with TRT while no association was found between obstructive azoospermia or NOA and TRT. Irrespective of the pre-operative diagnosis, a higher testosterone concentration before TESE was associated with a lower chance of needing TRT.
Conclusions: Men with obstructive azoospermia or NOA have a similar moderate risk of clinical hypogonadism after TESE, while this risk is much larger for men with Klinefelter syndrome. The risk of clinical hypogonadism is lower when testosterone concentrations are high before TESE.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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