Efficacy of Epley's maneuver plus betahistine in the management of PC-BPPV: A systematic review and meta-analysis.

Autor:	Li W; Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Sun J; Department of Otolaryngology, Head and Neck Surgery, Suining People's Hospital, Xuzhou, China., Zhao Z; Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Xu J; The First Clinical Medical College of Xuzhou Medical University, Xuzhou, China.; Otorhinolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Xuzhou, China., Wang H; The First Clinical Medical College of Xuzhou Medical University, Xuzhou, China., Ding R; The First Clinical Medical College of Xuzhou Medical University, Xuzhou, China., Zhang Y; Department of Otolaryngology Head and Neck Surgery, Xuzhou Cancer Hospital, Xuzhou, China.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2023 Mar 31; Vol. 102 (13), pp. e33421.
DOI:	10.1097/MD.0000000000033421
Abstrakt:	Background: To evaluate the efficacy of Epley's maneuver plus betahistine in the management of patients with posterior canal benign paroxysmal positional vertigo (PC-BPPV). Methods: Electronic databases including PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, and Wanfang were searched from their inception to April, 2022. The effect size was analyzed by calculating the pooled risk ratio estimates of efficacy rate, recurrence rate, and standardized mean differences (SMD) of dizziness handicap inventory (DHI) score with a 95% confidence interval (CI). Sensitive analysis was performed simultaneously. Results: A total of 9 randomized controlled trials with 860 PC-BPPV patients were included in the meta-analysis, in which 432 were treated with Epley's maneuver plus betahistine, and 428 received Epley's maneuver alone. The meta-analysis revealed that Epley's maneuver plus betahistine significantly improved DHI score than Epley's maneuver alone (SMD = -0.61, 95% CI -0.96 to -0.26, P = .001). In addition, both Epley's maneuver plus betahistine and Epley's maneuver groups had comparable outcomes in efficacy rate and recurrence rate. Conclusion: This meta-analysis shows that Epley's maneuver plus betahistine in PC-BPPV patients had favorable effects on DHI score. Competing Interests: The authors have no funding and conflicts of interest to disclose. (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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