HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer.

Autor: Raju GSR; Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul, 04620, Republic of Korea., Pavitra E; NanoBio High-Tech Materials Research Center, Biological Sciences and Bioengineering, Inha University, Incheon, 22212, Republic of Korea., Bandaru SS; Baton Rouge General Hospital, Baton Rouge, LA-70809, USA., Varaprasad GL; NanoBio High-Tech Materials Research Center, Biological Sciences and Bioengineering, Inha University, Incheon, 22212, Republic of Korea., Nagaraju GP; School of Medicine, Division of Hematology and Oncology, University of Alabama, Birmingham, AL, 35233, USA. pganji@uab.edu., Malla RR; Cancer Biology Laboratory, Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, 530045, India. dr.rrmalla@gmail.com., Huh YS; NanoBio High-Tech Materials Research Center, Biological Sciences and Bioengineering, Inha University, Incheon, 22212, Republic of Korea. yunsuk.huh@inha.ac.kr., Han YK; Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul, 04620, Republic of Korea. ykenergy@dongguk.edu.
Jazyk: angličtina
Zdroj: Molecular cancer [Mol Cancer] 2023 Mar 30; Vol. 22 (1), pp. 65. Date of Electronic Publication: 2023 Mar 30.
DOI: 10.1186/s12943-023-01765-3
Abstrakt: HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications.
(© 2023. The Author(s).)
Databáze: MEDLINE
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