Effects of prophylactic probiotics supplementation on infants born very preterm or very low birth weight.

Autor: Chiruvolu A; Division of Neonatology, Department of Pediatrics, Baylor University Medical Center at Dallas, Dallas, TX, USA. Arpitha.Chiruvolu@bswhealth.org.; Pediatrix Medical Group of Dallas, Dallas, TX, USA. Arpitha.Chiruvolu@bswhealth.org.; Department of Medical Education, Texas A&M University School of Medicine, Bryan, TX, USA. Arpitha.Chiruvolu@bswhealth.org.; Department of Women and Infants, Baylor Scott and White Medical Center-McKinney, McKinney, TX, USA. Arpitha.Chiruvolu@bswhealth.org., Hendrikson H; Division of Neonatology, Department of Pediatrics, Baylor University Medical Center at Dallas, Dallas, TX, USA.; Aramark Corporation, Houston, TX, USA., Hanson R; Department of Medical Education, Texas A&M University School of Medicine, Bryan, TX, USA., Reedy A; Department of Women and Infants, Baylor Scott and White Medical Center-McKinney, McKinney, TX, USA., Reis J; Division of Neonatology, Department of Pediatrics, Baylor University Medical Center at Dallas, Dallas, TX, USA.; Pediatrix Medical Group of Dallas, Dallas, TX, USA.; Department of Women and Infants, Baylor Scott and White Medical Center-McKinney, McKinney, TX, USA., Desai S; Division of Neonatology, Department of Pediatrics, Baylor University Medical Center at Dallas, Dallas, TX, USA.; Pediatrix Medical Group of Dallas, Dallas, TX, USA., Suterwala M; Division of Neonatology, Department of Pediatrics, Baylor University Medical Center at Dallas, Dallas, TX, USA.; Pediatrix Medical Group of Dallas, Dallas, TX, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2023 May; Vol. 43 (5), pp. 635-641. Date of Electronic Publication: 2023 Mar 30.
DOI: 10.1038/s41372-023-01657-w
Abstrakt: Objective: To evaluate the effects of guideline-driven prophylactic supplementation of a multi-strain neonatal intensive care unit-specific probiotic product on infants born very preterm (VP) or very low birth weight (VLBW).
Study Design: A prospective cohort of 125 infants born in one year after implementation who received probiotics were compared to a retrospective cohort of eligible 126 VP or VLBW infants who did not receive probiotics. The primary outcome of interest was necrotizing enterocolitis (NEC).
Result: The incidence of NEC decreased from 6.3 to 1.6%. After adjusting for multiple variables, there were no significant differences in primary or other outcomes of interest; odds ratio (95% confidence interval) NEC 0.27 (0.05-1.33), death 0.76 (0.26-2.21) and late-onset sepsis 0.54 (0.18-1.63). No adverse effects related to probiotics supplementation were observed.
Conclusion: Although nonsignificant, prophylactic probiotics supplementation in infants born VP or VLBW was associated with reduction of NEC.
(© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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